Staff Software Engineer

GuardantHealth

Hyderabad, TS, India Hybrid permanent

Posted: April 2, 2026

Job Description

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook.

We are seeking a highly accomplished Staff Software Engineer to lead the design and delivery of scalable, cloud-native platforms across enterprise and integration ecosystems. This role requires deep expertise in AWS cloud architecture, Java/Python development, and enterprise integration patterns, along with a focus on AI/ML-driven solutions.

Key Responsibilities

• Design and develop scalable systems using Java and/or Python
• Architect cloud-native solutions on AWS
• Build enterprise integration frameworks using APIs and event-driven patterns
• Develop microservices and distributed systems
• Integrate enterprise platforms like Salesforce and third-party systems
• Develop AI-powered solutions for automation and insights
• Ensure system scalability, security, and performance
• Drive CI/CD and engineering best practices
• Mentor engineers and provide leadership

Required Qualifications

• 8+ years of experience in software engineering with strong expertise in Java and/or Python
• Proven experience designing and scaling cloud-native applications on AWS
• Deep understanding of distributed systems, microservices, and API-driven architectures
• Strong experience in enterprise integration patterns, including asynchronous and event-driven systems
• Demonstrated ability to design modular, reusable platforms and components
• Experience integrating with enterprise systems such as Salesforce or similar platforms
• Strong knowledge of security, compliance, and access control frameworks
• Excellent communication skills with the ability to influence technical and non-technical stakeholders

Preferred Qualifications

• Experience with healthcare systems (HL7/FHIR)
• Experience with Salesforce integrations
• Exposure to AI/ML and LLM-based applications
• Experience with observability tools and DevOps practices

Success Metrics

• Deliver scalable AWS architectures
• Build reusable platforms to accelerate development
• Reduce system complexity and technical debt
• Improve system reliability and performance
• Drive AI-driven automation and insights

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