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Senior Bioinformatics Engineer

Natera

US Remote (US Remote-California) Remote permanent

Posted: February 23, 2026

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Quick Summary

A Senior Bioinformatics Engineer is required to lead the translation of validated research workflows into scalable bioinformatics pipelines, utilizing expertise in array-based bioinformatics and collaboration with product and development teams.

Job Description

Natera is a global leader in cell-free DNA (cfDNA) testing with a focus on women's health, oncology, and organ health. To bolster our oncology products, we are looking for a Senior Bioinformatics Engineer to provide technical expertise and process completion. Through collaboration between the product and development teams, the Senior Bioinformatics Engineer will help complete projects for the array of Oncology bioinformatics pipelines.

Responsibilities


Develop, maintain, and scale production-grade bioinformatics pipelines


Lead the translation of validated research workflows into scalable, automated, cloud-based production systems


Architect and drive automation initiatives to improve pipeline scalability, reliability, reproducibility, and turnaround time (TAT)


Design and oversee secure, high-throughput data transfer solutions across AWS accounts


Proactively identify bottlenecks and implement performance and cost optimizations


Contribute to long-term roadmap planning for automation and production pipeline evolution

Minimum Qualifications


Master’s degree in Bioinformatics, Computational Biology, Computer Science, or related quantitative field


5+ years of experience developing and operating bioinformatics or large-scale data processing pipelines in production environments


Strong proficiency in a production programming language (e.g., Python)


Extensive experience working in AWS or comparable cloud platforms


Proven ability to design scalable, automated systems with minimal manual intervention


Demonstrated experience owning automated pipelines end-to-end, including debugging across data, application, and infrastructure layers

Knowledge, Skills, and Abilities


Deep expertise with workflow orchestration tools (e.g., WDL, Nextflow, Snakemake)


Strong experience with Docker and containerized execution at scale


Advanced knowledge of AWS services such as S3, EC2, AWS Batch, Airflow, and IAM, including multi-account architectures


Experience leading automation efforts and driving technical improvements across teams


Experience handling large genomic datasets


Strong understanding of software engineering best practices, including CI/CD, unit testing, and test-driven development


Excellent communication skills and ability to influence technical direction across scientific and engineering stakeholders


Team player, self-motivated and detail oriented are essential

The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.
Remote USA
$117,400—$146,800 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com.

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents.

Link: https://www.natera.com/notice-of-data-collection-california-residents/

Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

For more information:
- BBB announcement on job scams
- FBI Cyber Crime resource page

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