Scientist/Sr. Scientist, High-Throughput Chemistry

tl;dr

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.

We are seeking first-rate high-throughput chemists to help us pioneer this uncharted frontier of drug discovery.

Our Story

A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition[1], but there are many other possible perturbation types whose potential remains unrealized.

General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).

Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines [2, 3, 4], and our technology holds the same promise.

The Position

We are seeking an experienced high-throughput chemist to be a founding member of our High-Throughput Chemistry Team. In this position, you will work in close conjunction with our Platform/Drug Discovery Team in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.

Your responsibilities will include designing, developing, and executing high-throughput chemistry workflows for small molecule synthesis, utilizing state-of-the-art automation tools and robotics to enhance reaction screening and parallel synthesis efficiency, supervising synthetic efforts with our CROs, managing compound libraries, and other aspects associated with generating high-throughput direct-to-biology chemical libraries for screening.

About You

High Agency. Initiative, independence, and self-accountability are some of our most valued traits.

Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.

Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.

Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.

Qualifications & Nice-To-Haves

• PhD in Chemistry, Chemical Biology, Medicinal Chemistry, or related field.

• Industry experience is desirable, but the ability to work hard and learn fast is more important to us.

• Deep understanding of small-molecule drug discovery and its relationship to human disease.

• Top-notch written and oral communication skills.

• Strong experience with:

• Organic synthesis, reaction optimization, and parallel chemistry workflows

• Designing, developing, and executing high-throughput chemistry workflows for small molecule synthesis

• Hands-on experience with high-throughput synthesis technologies and automation platforms (e.g., Chemspeed, Biotage, Tecan, or similar tools) for the rapid assembly and testing of compound libraries (direct-to-biology)

• Analytical techniques such as LC/MS, NMR, and HPLC for reaction monitoring and characterization

• Proficiency in:

• Compound management

• CRO management

• Maintaining and enhancing high-throughput instrumentation and automation systems.

• Handling and interpreting large experimental datasets; experience with data visualization tools

• Nice to have:

• Familiarity or experience with PROTAC/next-gen IPM technologies

• Able to work at the interface of chemistry and biology

• Prior experience on teams that have successfully advanced research to the clinic

• Experience managing junior scientists

Benefits

• Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.

• Top tier medical, dental, and vision coverage + One Medical membership.

• 401(k) retirement plans.

• Education and health/fitness incentive programs.

• Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.

• Reading budget! We will buy you books. 📚

• Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.

About Us

Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work, we're there to get things done, and when we're off, we're really off. 🌴

Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.

Writing First. We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.

Growth. As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.

Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)

More info at jobs.generalproximity.bio