Principal, Volume Forecasting

GeneDx (Nasdaq: WGS) delivers personalized and actionable health insights to inform diagnosis, direct treatment, and improve drug discovery. The company is uniquely positioned to accelerate the use of genomic and large-scale clinical information to enable precision medicine as the standard of care. GeneDx is at the forefront of transforming healthcare through its industry-leading exome and genome testing and interpretation services, fueled by the world’s largest, rare disease data sets. For more information, please visit www.genedx.com.

Summary

We are seeking a Principal, Volume Forecasting to own and advance GeneDx's end-to-end forecasting capability. This is a senior individual contributor role with high autonomy and broad cross-functional influence. You will build rigorous, data-driven models, drive full adoption of AI and automation tooling, lead forecasting cycles, and deliver the insights that shape strategic decisions across our diagnostics business — all with minimal leadership support in a fast-paced, high-growth organization.

Job Responsibilities

• Own the design, build, and continuous improvement of driver-based volume forecast models integrating historical trends, pipeline data, seasonality, payer/channel mix, and market intelligence across all product lines, architected to scale with new market entries and test launches

• Select and apply appropriate statistical and machine learning forecasting methodologies (e.g., ARIMA, exponential smoothing, regression, ensemble/ML methods) based on data characteristics, forecast horizon, and business context

• Drive full adoption of AI and automation across the forecasting scope, from data ingestion and feature engineering through model training, validation, and reporting, and replace manual processes with scalable, reproducible pipelines

• Lead monthly, quarterly, and annual forecasting cycles end-to-end, coordinating inputs from Sales, Marketing, Operations, and Finance to ensure alignment and accuracy

• Deliver objective forecasting scorecards tracking volume targets, forecast accuracy and variance; lead root-cause analysis in updates to Commercial, Operations, and Finance

• Produce and maintain a rolling volume forecast for incoming test volumes, delivered to the Supply Chain team on a defined cadence to enable downstream inventory planning and operational readiness

• Conduct scenario planning and sensitivity analyses to assess the impact of market changes, new product launches, pricing actions, and strategic initiatives on demand forecasts

• Partner with Commercial, Revenue, and Strategic Finance leaders to provide volume inputs for revenue forecasts, long-range plans, and board-level materials; support market sizing for new testing services

• Design and maintain high-visibility forecasting dashboards and automated reporting, ensuring stakeholders have self-service access to current forecasts, accuracy metrics, and variance tracking

• Serve as the organizational authority on volume forecasting methodology, data quality, and accuracy standards; present methodology choices and results to executive audiences

Education, Experience, and Skills

• Bachelor's degree in Statistics, Mathematics, Engineering, Economics, Finance, or a quantitative field; Master's degree preferred

• 8–12+ years of experience in Forecasting, Demand Planning, Analytics, or quantitative Consulting within diagnostics, healthcare, biotech, life sciences, or a comparably data-intensive industry

• Deep expertise in statistical forecasting techniques (e.g., ARIMA/SARIMA, exponential smoothing, time-series decomposition, regression) and practical experience applying machine learning methods (e.g., gradient boosting, random forests) to demand forecasting

• Proficiency in Python or R for model development and automation; ability to build production-quality, repeatable forecasting pipelines

• Proficiency in SQL and experience with cloud data platforms (e.g., Snowflake, BigQuery, Redshift); hands-on experience with Tableau or Power BI for dashboard design and automated reporting

• Experience with modern AI/ML forecasting tools and platforms (e.g., Prophet, statsmodels, scikit-learn, DataRobot, or equivalent); track record of driving AI adoption to improve forecast accuracy and efficiency

• Proven track record building driver-based and segment-level forecasts that inform capacity planning, resource allocation, and revenue decisions, with demonstrated accuracy improvement over time

• Demonstrated structured problem-solving ability: framing ambiguous business challenges, designing analyses, and distilling results into actionable insights for executive audiences

• Proven ability to operate independently with minimal direction — setting priorities, managing timelines, and driving outcomes across multiple concurrent workstreams

• Effective cross-functional partner and communicator who can translate forecasting insights into operational actions and influence senior stakeholders without positional authority

Work Environment

• This is a fully remote position. The employee will work from a home office or other suitable remote location with reliable high-speed internet access. Work is performed in a climate-controlled environment using standard office equipment including computer, phone, and video conferencing tools. Your standard work schedule and hours will be established in collaboration with your leader and may be adjusted to align with evolving business needs.

Physical Demands

This is a sedentary role requiring prolonged periods of sitting while working at a computer. Physical demands include:

• Sitting for extended periods (up to 8 hours per day)

• Repetitive use of hands and fingers for typing and mouse operation

• Visual acuity for reading computer screens and documents

• Ability to communicate effectively via phone and video calls

• Occasional lifting of up to 10 pounds (office supplies, equipment)

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position.

Pay Transparency, Budgeted Range
$150,000—$170,000 USD

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Science - Minded, Patient - Focused.

At GeneDx, we create, follow, and are informed by cutting-edge science. With over 20 years of expertise in diagnosing rare disorders and diseases, and pioneering work in the identification of new disease-causing genes, our commitment to genetic disease detection, discovery, and diagnosis is based on sound science and is focused on enhancing patient care.

Experts in what matters most.

With hundreds of genetic counselors, MD/PhD scientists, and clinical and molecular genomics specialists on staff, we are the industry’s genetic testing experts and proud of it. We share the same goal as healthcare providers, patients, and families: to provide clear, accurate, and meaningful answers we all can trust.

SEQUENCING HAS THE POWER TO SOLVE DIAGNOSTIC CHALLENGES.

From sequencing to reporting and beyond, our technical and clinical experts are providing guidance every step of the way:

TECHNICAL EXPERTISE

• High-quality testing: Our laboratory is CLIA certified and CAP accredited and most of our tests are also New York State approved.

• Advanced detection: By interrogating genes for complex variants, we can identify the underlying causes of conditions that may otherwise be missed.

CLINICAL EXPERTISE

• Thorough analysis: We classify variants according to our custom adaptation of the most recent guidelines. We then leverage our rich internal database for additional interpretation evidence.

• Customized care: Our experts review all test results and write reports in a clear, concise, and personalized way. We also include information for research studies in specific clinical situations.

• Impactful discovery: Our researchers continue working to find answers even after testing is complete. Through both internal research efforts and global collaborations, we have identified and published hundreds of new disease-gene relationships and developed novel tools for genomic data analysis. These efforts ultimately deliver more diagnostic findings to individuals.

Learn more About Us here.

Our Culture

At GeneDx, we are dedicated to cultivating an environment where creativity and innovation thrive. We believe in the power of community and collaboration, where diverse perspectives are embraced, and every voice contributes to our shared success. Our team is a vibrant mix of professionals who challenge and support each other in equal measure, fostering growth both personally and professionally. When you join us, you're not just taking on a job—you're joining a movement. A movement that champions curiosity, embraces change, and believes in making an impact, one patient at a time. Cultural principles we live by:  

• Be bold in our vision & brave in our execution. 

• Communicate directly, with empathy. 

• Do what we say we're going to do.  

• Be adaptable to change.  

• Operate with a bias for action.  

Benefits include:

• Paid Time Off (PTO)

• Health, Dental, Vision and Life insurance

• 401k Retirement Savings Plan

• Employee Discounts

• Voluntary benefits

GeneDx is an Equal Opportunity Employer.

All privacy policy information can be found here.