Vice President, US Field Sales - Commercial

“Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit https://mineralystx.com. Follow Mineralys on LinkedIn, Twitter and Bluesky”

Mineralys is a fully remote company.

Reporting to the Chief Commercial Officer, the Vice President of Sales is a newly created mission-critical leadership role responsible for designing the U.S. field sales strategy for lorundrostat. This executive will build the sales organization from the ground up, including structure, footprint, hiring, training, deployment, and performance management, while playing a key role in overall launch strategy and post-launch optimization.

This role requires a hands-on commercial builder with deep launch experience, strong payer-sensitive selling models, and the ability to scale a high-performance culture in a lean, fast-moving biotech environment.

Key Responsibilities

Pre-Launch Commercial & Sales Strategy

• Design the end-to-end U.S. sales strategy for lorundrostat, aligned with brand positioning, access strategy, and market dynamics.

• Define optimal sales force size, structure, targeting, and deployment model (geography, call points, specialty mix).

• Partner closely with Marketing, Market Access, Compliance, Medical Affairs, Regulatory, and Finance to ensure full launch readiness.

• Contribute to the development of sales forecasts, incentive compensation plans, and performance metrics.

• Lead input into commercial analytics, call planning, CRM, and technology infrastructure.

• Provide strategic input on pricing/access assumptions

Sales Force Build-Out

• Lead all aspects of field force hiring, including Regional Directors, District Managers, and Sales Representatives.

• Build scalable training, onboarding, and coaching programs in partnership with Commercial Operations and Training.

• Establish a high-performance, compliance-driven sales culture aligned with Mineralys’ values.

• Implement performance management, territory optimization, and succession planning processes.

Launch & Post-Launch Execution

• Lead national launch execution, including national sales meetings, training, and field enablement.

• Drive performance against launch goals through disciplined execution, field engagement, and data-driven decision making.

• Partner with Marketing to ensure flawless message pull-through and brand adoption.

• Optimize field strategy based on real-world performance, access dynamics, and competitive response.

Executive Leadership & Cross-Functional Partnership

• Serve as a core member of the Commercial Leadership Team.

• Partner with the Board, Executive Team, and Investors on sales performance, forecasts, and growth strategy.

• Ensure full compliance with all regulatory, legal, and corporate governance requirements.

Qualifications

Education & Experience

• Bachelor’s degree required; MBA or advanced degree preferred.

• 15+ years of progressive commercial and sales leadership experience in the biopharmaceutical industry.

• Proven track record of building and leading a U.S. sales organization for at least one successful product launch.

• Experience in cardiometabolic, cardiovascular, nephrology, or primary care-driven specialty markets strongly preferred.

• Prior experience at emerging / pre-commercial biotech companies highly desirable.

Leadership & Functional Expertise

• Demonstrated ability to build organizations from zero to scale.

• Strong experience with payer-sensitive selling models, reimbursement complexity, and specialty/primary care hybrid launches.

• Expertise in sales force effectiveness, incentive compensation design, and commercial analytics.

• Outstanding executive presence and the ability to influence at the Board and C-suite level.

• Deep understanding of promotional compliance, FDA regulations, and ethical selling.

Personal Attributes

• Entrepreneurial, builder mentality with comfort in ambiguity.

• Results-driven with strong judgment and accountability.

• Collaborative, low-ego leadership style suited for a small, high-caliber biotech culture.

• Strategic thinker who can also execute tactically.

This position is eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level.

US Salary Range: $280,000 - $310,000

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