Vice President, Pharmaceutical Sciences

Tangotherapeutics

Boston, MA (201 Brookline Avenue, Suite 901, Boston, MA) permanent

Posted: December 8, 2025

Job Description

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

Tango has an exciting new opportunity to join our team as VP, Pharmaceutical Sciences. Reporting to our President of R&D, you will be responsible for Drug Metabolism and Pharmacokinetics, Preclinical Safety and Clinical Pharmacology. You will collaborate with colleagues in drug discovery and drug development to deliver successful IND and NDA submissions. Your Role:

• You will be a recognized expert in clinical pharmacology with a track record of success in research and development

• Lead overall scientific, technical, and operational aspects of Pharmaceutical Science for R&D

• Recruit, develop and mentor talent as you build Pharmaceutical Sciences

• Collaborate with preclinical and clinical development teams to optimize study design and execution

• Represent Pharmaceutical Science as subject matter expert on R&D teams and governance boards

• Establish and maintain productive relationships with key internal business partners, consultants, and CROs

What You Bring:

• PhD or PharmD in clinical pharmacology, pharmacometrics, or related discipline with at least 15 years’ experience in the pharmaceutical and/or biotech industry

• Experience with small molecule drug development in oncology

• In-depth knowledge of drug metabolism, pharmacokinetics, biopharmaceutics, drug-drug interactions, and translational science

• Experience with health authority interactions

• Experience as lead or contributing clinical pharmacologist on a successful NDA submission

• Familiar with GLP, GCP, and ICH requirements

• Practical experience in modeling and simulation

• Highly motivated to work and collaborate in a fast-paced, high performing team

#LI-ONSITE

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Salary range
$272,400—$408,000 USD

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