Staff Scientist |Proteomics & Bioinformatics

The University of Notre Dame is more than a workplace; it is a vibrant, mission-driven community where every employee is valued and supported. Rooted in a tradition of excellence and inspired by our Catholic character, Notre Dame is committed to fostering an environment of care that nurtures the whole person—mind, body, and spirit. Here, you will find a deep sense of belonging, a culture that prioritizes well-being, and the opportunity to grow your career while being a force for good in the world. Whether contributing to world-class research, shaping the student experience, or supporting the University’s mission in other ways, you will be part of a dedicated team working to make a meaningful impact on campus and beyond. At Notre Dame, your work matters, and so do you!

The Staff Scientist will support proteomics and bioinformatics workflows within the Mass Spectrometry & Proteomics Facility. This role is responsible for executing advanced proteomics experiments, maintaining instrumentation, and partnering with researchers to design and implement high impact studies. The position requires strong technical expertise, hands on laboratory experience, and the ability to collaborate effectively with faculty, staff, and facility users.

Key Responsibilities

• Execute proteomics experiments using bottom up workflows, including sample preparation, data acquisition, and analysis
• Operate, maintain, and troubleshoot advanced instrumentation, including liquid chromatography systems and mass spectrometers
• Perform analyses using platforms such as Thermo Q-Exactive HF, Bruker timsTOF Pro, Sciex 6500/7600, and MALDI-TOF systems
• Support intact protein mass measurements and peptide mass mapping experiments
• Partner with Principal Investigators and researchers to design and implement proteomics studies
• Provide consultation on experimental design, data interpretation, and bioinformatics workflows
• Train and support facility users on proteomics techniques and instrumentation
• Contribute to proposal development for new instrumentation and facility enhancements
• Ensure proper documentation, data management, and adherence to laboratory best practices

• Ph.D. in Chemistry, Biochemistry, or a related field
• 1 to 2 years of relevant postdoctoral or professional experience
• Demonstrated expertise in proteomics sample preparation, data acquisition, and data processing
• Strong knowledge of proteomics, bioinformatics, and separation technologies

Preferred Qualifications:

• Experience with nano UHPLC systems (Waters M-Class, EvoSep, Bruker nanoElute or similar)
• Hands-on experience with high-resolution mass spectrometry platforms
• Familiarity with MALDI-TOF instrumentation for protein analysis
• Experience with proteomics data analysis tools and bioinformatics workflows

This role operates within a collaborative, core facility environment and requires a service oriented mindset, technical leadership, and a commitment to advancing research capabilities across the institution.

Please include Cover Letter and Resume with your application.

The University of Notre Dame seeks to attract, develop, and retain the highest quality faculty, staff and administration. The University is an Equal Opportunity Employer, and does not discriminate on the basis of race, color, national or ethnic origin, sex, disability, veteran status, genetic information, or age in employment. Moreover, Notre Dame prohibits discrimination against veterans or disabled qualified individuals, and complies with 41 CFR 60-741.5(a) and 41 CFR 60-300.5(a). We strongly encourage applications from candidates attracted to a university with a Catholic identity.