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Staff HPC Infrastructure Engineer

Guardant Health

Location not specified Remote permanent

Posted: December 9, 2025

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Job Description

Company Description

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn , X (Twitter) and Facebook .

About the Role:

You enjoy an agile, very fast paced and highly technical environment. You are a self-driven accomplished technologist who strives to be ever improving your skills, value to the company and improve the computational infrastructure. You are dedicated to engineering excellence yet pragmatic and flexible. You have the ability to maintain the day-to-day support SLA while running various key projects that move the business forward.

Essential Duties and Responsibilities:

Act as a technical lead in day to day operations
Help manage the HPC interconnects
Help integrate the HPC systems with the bandwidth on-demand system
Help integrate the HPC system with the single namespace storage system
Help integrate cloud bursting as part of the HPC abstraction work
Work with the networking infrastructure team to manage and optimize the connectivity to and from the HPC systems and locales
Help manage multiple HPC clusters and cluster file systems.
Help research, develop and implement the next generation HPC solution
Troubleshoot the production system stack down to source code level e.g. shell scripts, python and others.
Maintain, monitor, and support the infrastructure environment and/or facilities.
Use and maintain enhanced production monitoring and additional capability.
Support improvements for increased system reliability and performance.
Support multiple systems or applications of medium to high complex (complexity defined by size, technology used, and system feeds and interfaces) with multiple concurrent users, ensuring control, integrity, and accessibility.
Support systems at remote locations, including internationally
Work with offsite consultants to maintain the infrastructure
Work with vendors to troubleshoot, upgrade and repair systems as needed
Participate in a 24/7 on-call rotation

Required Qualifications:

B.S. in Computer Science or related field
4+ years of TCP/IP networking experience
2+ years of RDMA networking experience
4+ years of Linux/Unix administration, knowledge of Unix network protocols, TCP/IP network fundamentals, core infrastructure technologies and virtualization
2+ years of large-scale data storage and compute clusters (HPC) infrastructure
2+ years working in and with on-premise and cloud-based (AWS, Google, IBM and Azure) data-centers
2+ years of building software release and ops processes and automation toolset
2+ years providing documentation of system administration

Preferred Qualifications:

Cisco Certified Network Professional certification
Experience with Arista and compatible networking, up to and including 400 gb/s links
Experience with Mellanox infiniband fabric
Experience administering IBM’s General Parallel File System
Experience administering SLURM scheduler
Experience with using warewulf
Experience with cloud bursting technologies
Experience with wide area file systems
Experience with docker and container technologies
Experience with Kubernetes
Operating infrastructure compliant with HIPAA and SOX standards

Hybrid Work Model: This section is applicable to onsite employees who are eligible for hybrid work location as specified by management and related policies. Guardant has defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.

The annualized base salary ranges for the primary location and any additional locations are listed below. This range does not include benefits or, if applicable, bonus, commission, or equity. Each candidate’s compensation offer will be based on multiple factors including, but not limited to, geography, experience, education, job-related skills, job duties, and business need. Primary Location: Palo Alto, CA Primary Location Base Pay Range: $149,400 - $205,400 Other US Location(s) Base Pay Range: $127,000 - $174,600 If the role is performed in Colorado, the pay range for this job is: $134,500 - $184,850

Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.

Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to [email protected]

A background screening including criminal history is required for this role. GH will consider qualified applicants with criminal arrest or conviction histories in a manner consistent with applicable law including but not limited to the LA County Fair Chance Policies and the Fair Chance Act (Gov. Code Section 12952).

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

All your information will be kept confidential according to EEO guidelines.

To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants .

Please visit our career page at: http://www.guardanthealth.com/jobs/

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