Sr. Scientist, In Vivo Pharmacology

Location: Hamilton, Ontario

Onsite - 5 days a week

Fusion Pharmaceuticals, a member of the AstraZeneca Group, is a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines. Fusion connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumors. Fusion’s clinical portfolio includes but is not limited to: FPI-2265 targeting prostate specific membrane antigen (PSMA) for metastatic castration resistant prostate cancer currently in a Phase 2 trial; FPI-1434 targeting insulin-like growth factor 1 receptor currently in a Phase 1 trial; and FPI-2068, a bispecific IgG-based EGFR-cMET targeted radioconjugate currently in a Phase 1 trial. Fusion has multiple other pipeline programs that will soon be entering into early FIH trials. In addition, Fusion is pursuing combination programs between RCs and other therapeutic modalities including DNA Damage Response Inhibitors (DDRis) and immune-oncology agents. To support execution for these programs, Fusion has a fully operational Good Manufacturing Practice (GMP) compliant state-of-the-art radioconjugate manufacturing facility to meet supply demand for our growing pipeline of RCs.

Sr. Scientist, In Vivo Pharmacology

Fusion Pharmaceutical is seeking outstanding candidates for a Sr. Scientist in the In Vivo Pharmacology group, who will provide strategic and technical expertise in the design and execution of in vivo preclinical studies across therapeutic areas. The candidate will lead and work collaboratively with internal research teams to complete RC development programs. This position is lab-based at Fusion’s facilities in Hamilton, Ontario, Canada.

Responsibilities:

• Design, plan, and conduct mechanisms of action studies, therapeutic efficacy and biodistribution studies on radiopharmaceuticals in rodent models of cancer or other disease indications of interest

• The successful candidate will be expected to spend time in the lab and vivarium to execute in vivo studies experiments as needed, including cell culture, in-life monitoring, blood sampling, dosing, and ex vivo analysis (e.g. IHC, autoradiography, flow cytometry, biochemical assays)

• Identify and implement new pharmacology models, technologies, and strategies to develop targeted cancer radiotherapies

• Collaborate with cross-functional teams to provide scientific input and design, execute, and interpret studies, provide solution-oriented expertise to support key decision-making

• Mentor and train research staff ensuring regulatory compliance, technical excellence, high quality and documentation of results

• Write and review study documentation, analyze results, present findings, and contribute to authoring manuscripts and regulatory filings

• Work safely and in compliance with radioactive, biohazardous, animal ethics regulations and guidelines

• Develop an environment of collaboration, scientific excellence, open scientific exchange, and deep scientific rigor

Qualifications:

• Post-graduate degree in Molecular/Cell Biology, Biology, Biochemistry or related field with 5+ years of preclinical pharmacology experience with a Master’s degree, or 2+ years of experience with a Ph.D. degree

• Experience designing and performing in vivo pharmacology studies for preclinical drug development required (experienced with IV, IP, SC injections, oral gavage, blood collection, tissue dissections); biotech or pharmaceutical industry experience preferred

• Experience with development and validation of preclinical models of oncology; radiopharmaceutical experience an asset

• Must be agile and able to pivot, with demonstrated ability to lead and manage concurrent timelines and deliverables

• Demonstrate strong attention to detail and an approach centered on finding answers

• Strong documentation and record-keeping skills required

• Experience with the safe handling of radioactive and biohazardous materials an asset

WHY JOIN US?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients, and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth, and development. We’re on an exciting journey to pioneer the future of healthcare.

SO, WHAT’S NEXT?

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

Recognizing the importance of individualized flexibility, our ways of working allow employees to balance personal and work commitments while ensuring we continue to create a strong culture of collaboration and teamwork by engaging face-to-face in our offices 3 days a week. Our head office is purposely designed with collaboration in mind, providing space where teams can come together to strategize, brainstorm and connect on key projects.

Great People want to Work with us! Find out why:

• GTAA Top Employer Award for 10 years
• Top 100 Employers Award
• Canada’s Most Admired Corporate Culture
• Learn more about working with us in Canada
• View our YouTube channel

Are you interested in working at AZ, apply today!

AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment, assessment and selection process and may be requested by emailing [email protected].

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Annual base salary for this position ranges from 108,713.60 to 142,686.60.AstraZeneca is committed to providing fair and equitable compensation opportunities to all colleagues. Our compensation policies and practices have been designed to allow colleagues to progress through the salary range over time as they progress in their role. The range provided in this posting represents an offer pay range used in a majority of situations. The base pay offered will vary depending on multiple individualized factors, including the candidate's skills and experience, job-related knowledge, and other specific business and organizational needs.  In some cases, offers outside the range may also be considered to address unique circumstances.

In addition, our permanent positions offer an annual Variable Pay Bonus/Short Term Incentive opportunity as well as eligibility to participate in our equity-based long-term incentive program (if applicable to role).  Benefits offered for permanent roles include a competitive Flex Benefits & Retirement Savings Program, 4 weeks’ paid vacation, and annual Personal Days. Fixed Term Contract/Temporary positions (excluding students) are offered a Contract Benefits Program.

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This advertisement relates to a current vacancy.