Sr. Scientist, Diagnostic Assay Development

About the Role:

10x Genomics is establishing a diagnostics effort to translate our leading single-cell and spatial genomics technologies into impactful clinical applications. We are seeking a highly skilled and motivated Senior Scientist to join the Diagnostic Assay Development team. This is a hands-on bench scientist role with scientific ownership of assay development and optimization, combined with mentorship and technical leadership of junior staff. The Senior Scientist will directly execute, troubleshoot, and refine 10x Genomics–based assays to support development of robust Laboratory Developed Tests (LDTs).

What you Will Be Doing:

Assay Development & Execution

• Independently execute complex single-cell and spatial genomics workflows, including sample processing, library preparation, and sequencing.

• Serve as a hands-on technical expert for 10x Genomics platforms (e.g., Chromium, Xenium), with direct responsibility for assay performance.

• Systematically troubleshoot and optimize assay workflows to improve robustness, sensitivity, and reproducibility.

• Adapt, refine, and extend published protocols to meet clinical, regulatory, and scalability requirements.

• Design and execute feasibility studies evaluating new reagents, chemistries, instrumentation, and workflow improvements.

• Process diverse and challenging clinical sample types in support of clinical research and validation studies.

Analytical Validation & Documentation

• Design and execute experiments supporting analytical validation, including accuracy, precision, limit of detection, and reproducibility.

• Generate, review, and maintain high-quality laboratory documentation, including SOPs, validation protocols, and batch records, in accordance with Good Documentation Practices.

• Analyze assay performance metrics and quality control data to drive data-based technical decisions.

• Clearly present experimental data and scientific conclusions in team meetings and written reports.

Scientific Leadership & Mentorship

• Provide day-to-day technical guidance and mentorship to junior staff.

• Review experimental plans, data, and lab records generated to ensure scientific rigor and documentation quality.

• Support onboarding and training of new team members on 10x platforms, assay workflows, and laboratory best practices.

• Lead by example through hands-on bench work while contributing to team planning and prioritization.

Cross-Functional Collaboration

• Collaborate closely with R&D Scientists, Automation Engineers, Bioinformatics, and CLIA Operations teams to advance assay development milestones.

• Lead transfer of optimized assay workflows into the CLIA laboratory.

• Work with lab operations to maintain a high-quality laboratory environment, including inventory management, equipment calibration, and safety compliance.

To Be Successful, You Will Need:

• Ph.D. in Molecular Biology, Genetics, Biochemistry, or a related field, or M.S. with equivalent industry experience.

• 3+ years (Ph.D.), 5+ years (M.S.) of hands-on industry experience in molecular diagnostics or genomics assay development.

• Extensive, direct hands-on experience with 10x Genomics single-cell and/or spatial technologies, including troubleshooting and optimization.

• Demonstrated ability to independently adapt and refine published molecular biology protocols.

• Strong background in NGS workflows, including nucleic acid extraction, PCR/qPCR, and library preparation

• Experience working with complex or low-input clinical samples (e.g., FFPE tissue, primary tumor material)

• Experience with cell culture methods

• Prior mentoring or supervisory experience preferred

• Experience working in CLIA, CAP, or ISO 13485–regulated environments strongly preferred.

• Experience with automation or high-throughput workflows is a plus.

Preferences:

• Highly hands-on scientist who enjoys bench work and solving complex technical problems.

• Detail-oriented with a strong commitment to data quality and reproducibility.

• Effective communicator who collaborates well across disciplines.

• Comfortable balancing independent execution with mentorship and team leadership in a fast-paced environment.

Below is the base pay range for this full-time position. The actual base pay will depend on several factors unique to each candidate, including one’s skills, qualifications, and experience. At 10x, base pay is also just one component of the Company’s total compensation package. This role is also eligible for 10x’s equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. During the hiring process, your 10x recruiter can share more about the Company’s total compensation package.

Pay Range
$158,400—$214,400 USD

About 10x Genomics

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.

We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.

10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.