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Sr Manager, Software Engineering

Natera

US Remote (US Remote-California) Remote permanent

Posted: May 13, 2026

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Quick Summary

We are seeking a Sr Engineer to lead our software development team, responsible for designing and implementing genomics tertiary analysis software for our biotech company.

Job Description

POSITION SUMMARY

Natera is seeking a skilled, experienced and self-motivated Sr Engineering Manager to lead a software development team in a fast-growing biotech company. The team will be primarily responsible for architecting, implementing and supporting the genomics tertiary analysis software for all products across the Natera portfolio.

This role includes building and leading a distributed engineering team, working close to project management and product managers, and professional communication responsibilities on high-impact, high-visibility products. The individual will also be expected to drive process improvements and represent Natera tertiary software in regulatory and client audits.

RESPONSIBILITIES:


Lead


Build and lead successful high-performing teams


Provide technical leadership for software development engineers, both onsite and remote, to ensure on-time, on-budget development of high-quality software


Own technical design, architecture and implementation of genomics tertiary analysis software supporting thousands of samples a month for new and existing product across the Natera portfolio.


Collaborate with leads working in other products to identify similarities and drive standardization and efficiencies


Work close with 3rd party vendors to ensure the overall solution meets the aggressive business demands including performance, scalability, cost, security and regulatory compliance, etc


Drive implementation of the best engineering practices.


Own and contribute to release planning and management for the team's software applications


Manage


Manage multiple ongoing projects.


Work closely with project managers and technical product managers to understand requirements, size development effort, assign resources, identify dependencies and agree on schedule.


Communicate issues and risks to project managers and participate in activities such as root cause analysis, lessons learned among others.


Nurture


Guide the career development of team members, nurture their technical and interpersonal skills.


Provide continuous individual performance feedback focused on recognition of achievement and opportunities for growth.


Collaborate


Build and maintain ongoing strong working relationships with stakeholders, focus on building effective communication channels.


Facilitate collaboration among cross-functional development teams, software quality engineers, and product managers.


Effect change


Provide feedback to management and initiate change to optimize software development processes with a focus on quality, innovation, and efficient product delivery.


Own process improvement initiatives including primarily software development with interfaces to software testing and product management


Grow


Learn to write and review compliant documentation per CAP, CLIA, NYS DOH, FDA, HIPAA, NIST, and other standards


Learn to represent Natera tertiary software in audits with regulatory bodies, pharmaceutical companies, and other clients


Learn software / architecture in depth with an eye toward broader responsibilities

QUALIFICATIONS:


BS or MS degree in Computer Science, Bioinformatics or equivalent demonstrated industry experience


5+ years of proven track record of building and managing high performing engineering teams


Extensive experience building genomics tertiary analysis software for clinical and research use


8+ years of experience in software development using Java or similar language


Experience developing software in a regulated environment


Experience in and aptitude for leading remote teams

KNOWLEDGE, SKILLS, AND ABILITIES:


Proven record of managing highly effective engineering teams


Experience in building robust enterprise applications using Java or Python


Expertise in building highly scalable and easy to maintain distributed systems


Hands-on coding, design, architecture, and agentic AI skills


Strong analytical and problem-solving skills


A passion for people management and mentorship


Excellent verbal and written communication skills


Ability to collaborate cross-functionally and communicate effectively with reports, peers, and stakeholders


Demonstrate initiative with a proactive approach to addressing issues and finding creative solutions


Must demonstrate strong work ethic, work well under pressure and stressful circumstances


Experience in genomics secondary analysis solutions is a plus

The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.
Remote USA
$156,000—$195,000 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com.

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents.

Link: https://www.natera.com/notice-of-data-collection-california-residents/

Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

For more information:
- BBB announcement on job scams
- FBI Cyber Crime resource page

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