Sr. Director, Marketing

The Senior Director, Marketing, will play an integral role in bringing our groundbreaking AAV gene therapies to patients with genetic cardiomyopathies. In this high-impact role, the incumbent will build Lexeo’s marketing function from the ground up, shaping brand strategy, market development, and launch readiness for first-in-class therapies poised to transform care in cardiac genetic diseases with high unmet need. You’ll combine strategic vision with hands-on execution, crafting compelling scientific narratives, driving disease awareness, and preparing providers, patients, and payers for a new era in gene therapy. This is a rare opportunity to define how life-changing science becomes real-world medicine.

Primary Responsibilities:
• Build, lead, and scale the marketing function; manage budget, resources, vendor/agency relationships, and KPIs tied to demand generation and launch readiness
• Develop and execute integrated brand and launch planning strategies for Lexeo’s cardiac pipeline (initially US-focused and future global expansion)
• Shape and evolve Lexeo’s brand story as a leader in genetic cardiovascular medicine, partner with external communications (media, PR, social, thought leadership, IR)
• Build deep customer segmentation and personas across key stakeholders: opinion leaders, cardiologists, genetic specialists, patient advocacy groups, and other members of multi-disciplinary care teams
• Lead disease awareness and diagnosis-activation initiatives in partnership with Medical and Patient Affairs
• Define evidence needs and value propositions for payer engagement, pricing, and provider strategies
• Contribute to strategic planning and commercial prioritization across the portfolio
• Develop messaging frameworks for HCPs, patients, and payers, emphasizing genetic causes, durability, and impact of therapies.
• Expand Lexeo commercial infrastructure with an eye towards commercial launches, including data and analytics, field reporting, patient support and commercial intelligence
• Serve as the commercial voice on cross-functional teams, ensuring alignment from early stage through launch
• Collaborate with new and growing field teams, including market access, medical affairs, field reimbursement and sales

Required Skills & Qualifications:
• Bachelor’s in Life Sciences, Marketing, or Business required; MBA, PharmD, or PhD preferred.
• 10+ years in life sciences marketing or launch planning (rare disease, gene therapy, advanced biologics), with both upstream (strategy, portfolio) and downstream (brand, digital) experience.
• Experience in developing launch readiness for novel therapies (cell/gene therapies, biologics in rare/monogenic disease); experience in specialty/high-science areas is preferred
• Strong scientific acumen; familiarity with AAV platforms, manufacturing, and regulatory pathways.
• Deep competency in digital/omnichannel marketing: CRM, automation, SEO/SEM, analytics, content strategy.
• Strong cross-functional collaboration skills and ability to influence senior leadership
• Ability to translate complex science into compelling commercial narratives

About Lexeo

Lexeo Therapeutics is a clinical-stage genetic medicine company headquartered in New York City, pioneering cardiac genetic medicine candidates to treat the root causes of inherited cardiovascular diseases. Our lead program, LX2006, targets cardiomyopathy associated with Friedreich’s Ataxia and anchors a broader pipeline addressing genetically defined conditions such as hypertrophic and arrhythmogenic cardiomyopathies. Backed by a strong financial foundation, Lexeo is positioned to translate groundbreaking science into durable clinical impact.

Our work culture is a hybrid model with 2 days/week in the New York City office and 3 days working from home.

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.