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Senior Software Engineer II, Full-Stack

Genedx

Remote Remote permanent

Posted: March 11, 2026

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Quick Summary

A Senior Software Engineer II, Full-Stack working remotely, responsible for designing and developing software products, with a strong track record in understanding business needs, effectively communicating with stakeholders and delivering impactful results.

Job Description

Summary

As a public and profitable company, we have ambitious plans to scale and enhance our products and services. We’re looking for software engineers who can work holistically to design strategic solutions that go beyond just writing code. A strong track record in understanding business needs, communicating effectively, and delivering impactful results is essential, along with leadership qualities to guide and inspire colleagues.

Job Responsibilities

As a Senior Software Engineer, you'll play a key role in advancing our technology platform and building software products that make a meaningful impact. You’ll have the opportunity to lead technical efforts spanning multiple months across a large-scale system. You'll be expected to propose novel solutions to real-world business challenges, work cross-functionally with engineering and non-engineering peers, and drive results that enhance our user experiences and business workflows.

Day to day tasks may include:

• Dive into unfamiliar code to troubleshoot or add a new feature

• Participate in feature development of larger projects

• Technically lead smaller projects

• Participate in Support tasks, including off-hours and weekend on-call rotations.

• Propose technical designs, considering standard patterns, tradeoffs, and maintainability

• Provide thorough and meaningful code reviews

• Work with legacy as well as novel code bases

• Prototype, develop, and debug new features

• Implement and maintain DevOps cloud patterns

People Manager

• No

Education, Experience, and Skills

• Proficiency in at least 3 software languages, with a demonstrated ability to quickly learn new ones as needed. Python is highly desired, but other languages such as C#, Java, Javascript/Typescript, or others are acceptable.

• 5+ years experience developing back-end services and APIs in a distributed, service-oriented architecture.

• 5+ years experience building large-scale front-end applications using modern frameworks (React highly desired, but Vue, or Angular are acceptable).

• 5+ years experience with data modeling using multiple database and storage types

• 3+ years experience designing and deploying services in the cloud (e.g. AWS, GCP, Azure, OCI).

Bonus points for:

• Prior healthcare / health tech experience, or experience in other regulated industries, particularly with data privacy and compliance requirements

• Kubernetes

Certificates, Licenses, Registrations

• None

Physical Demands

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodation may be made to enable individuals with disabilities to perform the essential functions.

• While performing the duties of this job, the employee is frequently required to stand; sit and use hands to finger, handle, or feel.

• Ability to stand, walk, and sit for extended periods.

Work Environment

• Work is primarily performed in a remote office setting.

• Extended periods of stationary computer work.

Acknowledgements

The above job description is not intended to be an all-inclusive list of duties and standards of the position. Incumbents will follow any other instructions, and perform any other related duties, as assigned by their supervisor.

Pay Transparency, Budgeted Range
$170,000—$180,000 USD

~

Science - Minded, Patient - Focused.

At GeneDx, we create, follow, and are informed by cutting-edge science. With over 20 years of expertise in diagnosing rare disorders and diseases, and pioneering work in the identification of new disease-causing genes, our commitment to genetic disease detection, discovery, and diagnosis is based on sound science and is focused on enhancing patient care.

Experts in what matters most.

With hundreds of genetic counselors, MD/PhD scientists, and clinical and molecular genomics specialists on staff, we are the industry’s genetic testing experts and proud of it. We share the same goal as healthcare providers, patients, and families: to provide clear, accurate, and meaningful answers we all can trust.

SEQUENCING HAS THE POWER TO SOLVE DIAGNOSTIC CHALLENGES.

From sequencing to reporting and beyond, our technical and clinical experts are providing guidance every step of the way:

TECHNICAL EXPERTISE

• High-quality testing: Our laboratory is CLIA certified and CAP accredited and most of our tests are also New York State approved.

• Advanced detection: By interrogating genes for complex variants, we can identify the underlying causes of conditions that may otherwise be missed.

CLINICAL EXPERTISE

• Thorough analysis: We classify variants according to our custom adaptation of the most recent guidelines. We then leverage our rich internal database for additional interpretation evidence.

• Customized care: Our experts review all test results and write reports in a clear, concise, and personalized way. We also include information for research studies in specific clinical situations.

• Impactful discovery: Our researchers continue working to find answers even after testing is complete. Through both internal research efforts and global collaborations, we have identified and published hundreds of new disease-gene relationships and developed novel tools for genomic data analysis. These efforts ultimately deliver more diagnostic findings to individuals.

Learn more About Us here.

Our Culture

At GeneDx, we are dedicated to cultivating an environment where creativity and innovation thrive. We believe in the power of community and collaboration, where diverse perspectives are embraced, and every voice contributes to our shared success. Our team is a vibrant mix of professionals who challenge and support each other in equal measure, fostering growth both personally and professionally. When you join us, you're not just taking on a job—you're joining a movement. A movement that champions curiosity, embraces change, and believes in making an impact, one patient at a time. Cultural principles we live by:  

• Be bold in our vision & brave in our execution. 

• Communicate directly, with empathy. 

• Do what we say we're going to do.  

• Be adaptable to change.  

• Operate with a bias for action.  

Benefits include:

• Paid Time Off (PTO)

• Health, Dental, Vision and Life insurance

• 401k Retirement Savings Plan

• Employee Discounts

• Voluntary benefits

GeneDx is an Equal Opportunity Employer.

All privacy policy information can be found here.

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