Senior Scientist, Translational Neuroscience

Who We Are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description:

We are seeking a highly skilled in vivo scientist to significantly advance neurodegenerative disease research, with a focus on Parkinson's disease. The individual will be instrumental in designing, executing, and interpreting experiments using rodent models to investigate neurological and aging disorders and evaluate therapeutic interventions. This will enhance the Translational Neuroscience team's in vivo research capacity, establish advanced models for due diligence, and test novel drug mechanisms of action. The scientist will also be crucial in modeling novel aspects of neurodegenerative diseases, incorporating human cohort findings, and setting up mechanistic models to test hypotheses from new target discovery.

Responsibilities:

• Develop and characterize novel in vivo models of neurodegeneration and age-related biology

• Design and execute in vivo functional experiments for target validation and mechanistic biology studies

• Conduct broad animal behavioral assessments to characterize neurological phenotypes

• Analyze, interpret, and communicate data and results effectively to the team

• Document data and protocols in accordance with Calico guidelines, maintaining meticulous records of experiments, data, and findings

• Contribute to experimental design, data interpretation, and presentation of results

• Collaborate effectively across multiple functional teams

• Adhere to all animal welfare regulations and institutional guidelines

Position Requirements:

• Ph.D. in Neuroscience, Biology, Pharmacology, or a related field, with 5+ years relevant postdoctoral or equivalent industrial experience

• In Vivo Expertise:

• Experience in live animal surgeries

• Extensive experience with broad animal behavioral assessment techniques

• Expertise in rodent handling, compound treatments, micro sampling, and CNS tissue harvests

• Experience in longitudinal monitoring of behavior and colony maintenance

• Laboratory Skills:

• Practical experience in cellular assays

• Skilled in cells and tissue immunohistochemistry and microscopy, including basic histological techniques for tissue processing, staining, and image analysis

• Analytical & Communication Skills:

• Excellent communication, interpersonal, and organizational skills

• Ability to work independently and collaboratively within multidisciplinary team

• Meticulous with attention to detail

• Must be willing to work onsite 5 days a week

The estimated base salary range for this role is $166,000 - $191,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.