Senior Scientist, Radiochemistry

Actithera is a radiopharmaceutical biotech company, co-headquartered in Oslo and Cambridge, Massachusetts, founded in 2021. The company applies a chemistry-first approach to design next-generation radioligand therapies (RLTs) that deliver potent, tumor-focused radiation while sparing healthy tissue—guided by an isotope-agnostic and platform-enabled strategy to optimize tumor retention and therapeutic index. Actithera’s vision is rooted in precision molecular design and a deeply collaborative culture, with a shared mission to transform the lives of cancer patients through innovative science.

We are seeking an experienced and skilled Senior Scientist to join our R&D team in Oslo. The Senior Scientist will work side by side with colleagues in the laboratory while taking a scientific leadership role in the manufacture of drug products for preclinical studies, as well as in the design, execution, and troubleshooting of radiochemistry, analytical, and CMC activities. In this role, the Senior Scientist will guide and support junior team members in experimental execution, data interpretation, and best laboratory practices. This position combines hands-on experimental work with scientific leadership to support discovery programs, IND/CTA-enabling activities, and early clinical manufacturing.

Key Responsibilities

Prepare radiolabeled compounds for in vitro, in vivo, and ex vivo studies, coordinating closely with pharmacology teams.

Design, develop, and execute radiolabeling protocols for small molecules and other targeting vectors using clinically relevant radionuclides (e.g. Lu-177, Ac-225, In-111, or others as appropriate).

Develop, optimize, and maintain analytical methods for radiopharmaceutical drug products, including radio-HPLC, iTLC, and supporting non-radioactive methods, ensuring suitability for development, transfer, and clinical use.

Lead method optimization, validation/qualification, and troubleshooting to ensure robust, reproducible radiochemistry and analytical data, including impurity profiling, stability assessment, and formulation-related effects.

Support CMC development and IND/CTA-enabling activities, including preparation of technical documentation, analytical method descriptions, and process narratives.

Support technology transfer of radiolabeling and analytical methods to external CDMOs, including preparation of transfer packages and provision of technical support.

Act as a technical expert during CDMO troubleshooting, supporting investigations of deviations, low yields, analytical failures, impurity issues, or robustness challenges during clinical manufacturing.

Support clinical manufacturing activities, including preparation and review of radiolabeling instructions, batch documentation, and analytical release strategies.

Analyze, interpret, and present experimental findings and technical insights to project teams.

Mentor and support scientists in experimental execution, data analysis, and best practices in radiochemistry, analytics, and CMC-related laboratory work.

Collaborate cross-functionally with medicinal chemistry, in vitro pharmacology, in vivo pharmacology, QA, regulatory, and external partners to integrate radiochemistry and CMC into overall program strategy.

Contribute to publications, patents, and external presentations as appropriate.

Ensure compliance with radiation safety regulations, GMP-relevant procedures (as applicable), and internal SOPs, actively promoting best practices and maintaining a safe laboratory environment.

Qualifications

PhD in chemistry, radiochemistry, pharmaceutical sciences, or a related discipline with 3+ years of postdoctoral or industry experience; or MSc with 6+ years of relevant industry experience.

Strong hands-on expertise in radiochemistry and radiolabeling of therapeutic or imaging radiopharmaceuticals.

Demonstrated experience in analytical method development for radiopharmaceuticals, including radio-HPLC and iTLC; familiarity with broader analytical techniques is an advantage.

Experience supporting CMC development, technology transfer, and/or clinical manufacturing, including interaction with external CDMOs.

Familiarity with IND/CTA-enabling activities and regulatory expectations for analytical and CMC documentation is highly desirable.

Demonstrated ability to design, analyze, and interpret complex experimental data.

Proven track record of scientific leadership, mentoring, and effective cross-functional collaboration.

What We Offer

Opportunity to work at the forefront of radioligand therapeutic discovery and clinical translation with a team committed to scientific excellence and patient impact.

Competitive compensation and benefits package.