Senior Scientist, Quantitative Mass Spectrometry

Do you have expertise in mass spectrometry and want to be part of a team who has direct impact on drug development? 

We have a great opportunity for a motivated mass spectrometry expert to join our Integrated Bioanalysis (IBA) team as a Senior Scientist. The role is located at our vibrant R&D site in Gothenburg, Sweden. 

About Discovery Bioanalysis:
Discovery Bioanalysis (DxBA) is a global department within Integrated Bioanalysis, Clinical Pharmacology & Safety Sciences (CPSS), supporting AstraZeneca’s portfolio from early discovery through clinical development. The team applies advanced analytical technologies, including immunoassay, quantitative LC-MS, flow cytometry, multi-omics, and spatial biology to generate high-confidence datasets for decision-making at key project milestones. Working closely with cross-functional project-teams, the group provides comprehensive support across discovery, preclinical, and clinical phases, contributing to the advancement of therapies for complex diseases.

What you’ll do?
As part of the Discovery Bioanalysis Team, you will develop and validate bespoke mass spectrometry assays to assess pharmacokinetics and target engagement biomarkers across diverse therapeutic modalities. The role involves designing, executing, and transferring complex assays using advanced instrumentation to support discovery, preclinical and clinical studies. You will ensure assays are fit for purpose to meet their intended context of use & will collaborate with internal and external partners, reviewing and analyzing data; and troubleshooting assay performance. As a Subject Matter Expert, you will be responsible for enhancing the IBA reputation for scientific excellence by presenting at internal and external meetings, and publishing manuscripts.

Alongside the core laboratory role, you may have the opportunity as a Discovery Bioanalytical lead to work within a dynamic cross-functional team in a matrixed environment, defining and executing on tailored & focused project-specific bioanalytical strategies supporting decision-making and advancing the pipeline. You will work in close partnership with key stakeholders across the business, input to project strategy and delivery, managing expectations whilst interfacing with experienced and highly skilled bioanalytical scientist colleagues or our partnered labs. You will have the opportunity to influence decisions from early discovery through late-stage development and have an immediate and lasting impact to our diverse pipeline.

Essential requirements:
•    PhD (1+ years’ experience), or BSc (5+ years’ experience) in biology, chemistry, or related field with significant relevant experience
•    Proven expertise in mass spectrometry and proven track record to apply state-of-the-art mass spectrometry instrumentation to address sophisticated bioanalytical challenges related to drug discovery and development
•    Development, validation/qualification of LC-MS assays in support of pharmacokinetic (PK), toxicokinetic (TK), Biomarker Quantification in variety of biological matrices
•    Deep familiarization and practical experience with protein/peptide chemistry, peptide mass spectrometry, and quantitative bioanalysis
•    Demonstrate competency in troubleshooting, optimization and implementation of challenging and innovative LC-MS/MS assays

Desirable requirements:
•    Perform complex data analysis on acquired datasets, collaborate with pharmacologists, statisticians, data scientists across global teams
•    Independently design LC-MS method development and qualification experiments for ADC constructs and novel protein biotherapeutics or protein biomarkers, including but not limited to: various antibody-free and immunocapture approaches, LC parameters/gradients, MS acquisition settings, and data processing methods.
•    Demonstrated knowledge and independent application of technical expertise in protein biotherapeutic DMPK, including but not limited to: PK/TK study bioanalysis planning, LC-MS sample analysis results interpretation, guidelines for repeat sample reanalysis, and PK parameters.

What’s next?
Are you ready to make a meaningful and lasting difference? Apply today and join us in our mission to push the boundaries of science and transform medicine. Please submit your application; CV and cover letter, before April 10, 2026.

Date Posted

24-mars-2026

Closing Date

10-apr.-2026

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.