Senior Scientist Mass Spectrometry (Proteomics)

About Oxford BioTherapeutics: 

Oxford BioTherapeutics is a clinical-stage biotechnology company focusing on the development of antibody therapeutics for the treatment of cancer. OBT’s OGAP-verify® platform is the world's largest, cancer specific, membrane protein library, directly measuring plasma membrane protein expression in patient tumours. OGAP is used to identify novel, highly tumour specific antigens for novel first-in-class ADC, T-cell Engager (TCE) and Chimeric Antigen Receptor (CAR-T) targets.  Our lead asset, OBT076, is an Antibody Drug Conjugate (ADC) in Phase 1b clinical development.  Our clinical and pre-clinical pipeline of novel biologics is balanced between internal programs, focused on ADCs and checkpoint regulators, and externally partnered programs with key innovators in oncology such as Roche, GSK and Zymeworks. 

Purpose of the Role 

The role will lead the mass spectrometry proteomics laboratory work at OBT’s Oxford research facility. The role will generate quantitative proteomics data from human tissues in support of OBT’s OGAP verify, oncology target discovery platform, with the aim of identifying novel oncology drug targets for development with antibody-based drug therapies (ADCs, TCEs, CAR-T, Radiopharmaceuticals) 

Roles and Responsibilities:   

Maintain, optimise and operate Thermo Exploris nano-LC mass spectrometers 

Train staff in mass spectrometry and proteomics 

Conduct routine data generation on human oncology samples 

Work with bioinformatics research function to analyse data 

Work with the wet lab to support human tissue analysis 

Work with line manager to generate data in support of existing collaborations and new business development opportunities. 

Perform method development work as required. (This is only a minor requirement of the role) 

Please note the roles and responsibilities for the position include but are not limited to the above. 

Knowledge, Experience, and Skills: 

Essential: 

PhD in proteomics, mass spectrometry, protein biochemistry or bio/analytical chemistry 

Located/ability to relocate to Oxford/Oxfordshire area 

Knowledge of running a mass spectrometry laboratory through post-doctoral work in either CRO, commercial, service or academic lab experience 

Knowledge of operating, maintaining and troubleshooting Thermo mass spectrometers and associated software and nano-HPLC systems 

Ability to accurately record data in Electronic Lab Notebook systems 

Knowledge of quantitative proteomics methods 

Line management experience 

Ability to deliver critical data to tight deadlines 

Highly organised and methodical 

Ability to train and inspire others  

Ability to synthesise and communicate findings within the internal team (with possible external presentations) 

Desirable: 

3+ years post-doctoral experience 

Experience in a commercial and time critical environment 

Knowledge or proteomics bioinformatics approaches and software 

Knowledge of protein biochemistry and chromatography methods 

Knowledge of oncology would be desirable, but not essential 

Knowledge of proteogenomic methods and NGS would be desirable 

Any knowledge of targeted quantitation methods would be useful 

One of our top priorities is to maintain the health and wellbeing of our employees and their families. To achieve this goal, we offer comprehensive benefits. 

Benefits Offered: 

Private health care (Bupa) 

Health Cash Plan 

Generous pension scheme with potential employer contribution of up to 10% (based on match contributions) 

Discretionary annual bonus scheme 

Free onsite parking 

Office snacks 

Enhanced holiday entitlement above statutory minimum plus public holidays  

Employee Referral Bonus Program 

Annual training budget for professional development 

New hire share options 

Team building events and activities 

Equal Opportunities Statement 

We are committed to equality of opportunity for all employee and applications from individuals are encouraged regardless of age, disability, sex, gender reassignment, sexual orientation, pregnancy and maternity, race, religion or belief and marriage and civil partnerships. 

Why Join Us 

 We promote a culture of innovation, responsibility, and collective commitment to our goals. We believe that by bringing together our diverse skills and perspectives, we can develop novel, robust cures for one of today’s most challenging health conditions. 

Our people often describe OBT’s culture as friendly, collaborative, and hard‑working. We recognise that our team is only as strong as the individuals within it, which is why, in addition to hiring the best people, we strive to provide a working environment based on cooperation, creativity, and mutual respect.