Senior Scientist – In Vivo Mouse Genome Engineering

Are you an in vivo biologist who thrives at the bench and wants to turn cutting-edge genome engineering into transformative therapies for rare diseases? Do you want to collaborate across disciplines to translate innovative editing technologies into robust, decision-driving in vivo data. Join us to design, deliver, and optimize next‑generation editors directly in mice to advance curative gene therapies. We have a great opening for a Senior Scientist with demonstrated expertise in in vivo mouse studies and genome engineering. You will join the Genome Engineering In Vivo Models team , within Discovery Sciences and focuse on in vivo genome modification in mouse models. The role is located at our vibrant R&D site in Gothenburg, Sweden . What you’ll do? This is a laboratory-based role , where you will plan and conduct end to end mouse studies, including dosing, tissue collection, necropsy, and sample processing in accordance with ethical and regulatory standards. You will also prepare and administer CRISPR/Cas9, base and prime editors, guide RNAs, and donor templates via appropriate routes (e.g., IV, IP, IT, IM) and modalities (e.g., AAV, LNP, viral and non viral systems). Typical accountabilities will include: Data generation and analysis: Quantify on target editing and functional outcomes using NGS (targeted amplicon or capture), qPCR/dPCR, and protein/biomarker assays; contribute to off target risk assessment Study design and optimization: Optimize dose, route, schedule, tissue targeting, and delivery vehicle selection across relevant strains and disease models to meet program objectives Documentation and reporting: Maintain accurate records, ensure data integrity and traceability, and deliver clear study reports and presentations to drive project decisions Cross-functional collaboration: Partner with genome engineering, pathology, and bioinformatics teams to troubleshoot, interpret data, and advance milestones Essential requirements for the role: Ph.D. or equivalent industrial/academic experience in a relevant discipline (e.g., in vivo pharmacology, molecular biology, genetics, biomedical engineering) Hands on expertise with in vivo mouse procedures Practical experience with genome editing technologies; experience translating in vitro to in vivo preferred Proficiency in analysis of genome editing outcomes from in vivo samples (NGS, qPCR/dPCR, protein/biomarker quantification) Strong organizational, documentation, and data management skills; proficiency with electronic lab notebooks and sample tracking Effective communication skills and a collaborative working style with a delivery focus Compliance with institutional animal care and welfare standards is required; relevant certifications are preferred Why AstraZeneca? At AstraZeneca, we are united by a common purpose: to push the boundaries of science to deliver life changing medicines. You will join an inclusive, science led organization with the resources and cross functional expertise to translate innovative genome engineering into therapeutic impact. What’s next? If this sounds like the place and job for you – welcome to apply today! We look forward to get to know you better. Send in your application no later than January 16, 2026 . For more information about the position please contact hiring manager Michelle Porritt at michelle.porritt@astrazeneca.com Please note: Due to the holiday season, our response to your application may take longer than usual. Thank you for your patience—we will follow up when we return in January. Date Posted 19-dec.-2025 Closing Date 16-jan.-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.