Senior Scientist, Clinical Data

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

The Clinical Data Scientist will play a critical role in analyzing and interpreting clinical trial data, developing scientific materials, and supporting clinical development strategy across Arrowhead’s pipeline. This individual will be part of the Clinical Development team and work with Biostatistics, Medical Writing, and other cross-functional R&D teams to translate complex datasets into meaningful scientific insights that inform internal decision-making, regulatory strategy, and external communication.

This position requires a PhD-trained scientist with statistical knowledge, analytical capabilities, scientific storytelling skills, and the ability to operate in a fast-paced biotech environment.

This is a fulltime, onsite position based from Arrowhead’s Corporate Headquarters in Pasadena, CA or San Diego, CA.

Responsibilities

Clinical Data Analysis & Scientific Interpretation

• Perform in-depth clinical data analyses to support ongoing studies and development programs.

• Interpret clinical datasets and translate findings into clear, actionable insights.

• Develop internal presentations and communicate results to key stakeholders, including senior leadership.

• Identify trends, signal detection insights, and emerging data patterns to support program strategy.

• Respond to ad hoc clinical data questions from cross-functional R&D teams.

Abstract Development & Scientific Communication

• Draft early-stage scientific abstracts

• Prepare and refine slide decks summarizing clinical data for internal and external audiences.

• Support development of scientific narratives aligned with emerging data.

• Partner with Medical Writing and Clinical Development to ensure data integrity and scientific accuracy.

Clinical Development Support

• Assist Clinical Development with protocol input and clinical trial design considerations.

• Contribute to endpoint selection, subpopulation strategy, and exploratory analyses.

• Support preparation for key data readouts and milestone events.

• Provide data-driven input into broader R&D strategic discussions.

Cross-Functional Collaboration

• Partner with Biostatistics to ensure appropriate analytical approaches.

• Collaborate with Clinical Operations and Data Management to ensure data quality and readiness.

• Support Medical Affairs and other functions in understanding emerging clinical insights.

• Contribute to regulatory readiness by ensuring clarity and consistency of clinical data interpretation.

Requirements

• PhD in a biological, biomedical, or medical discipline.

• 3+ years of experience in biotech, pharmaceutical, academic translational research, or clinical data analysis roles.

• Strong experience analyzing and interpreting clinical data.

• Background in medical writing, clinical data science, or translational research.

• Experience supporting clinical trial design.

• Experience in early-stage development programs.

• Familiarity with statistical tools (e.g., SAS, R, Python) or data visualization platforms

• Experience preparing scientific presentations and slide decks for internal stakeholders.

• Experience drafting or contributing to scientific abstracts or publications.

• Excellent written and verbal communication skills.

• Strong analytical thinking and ability to synthesize complex datasets.

• Ability to operate independently and manage multiple priorities.

California pay range
$140,000—$170,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.

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