Senior Scientist, Cell Therapy

We are seeking a highly-motivated and independent Senior Scientist with demonstrated experience in Cellular Therapy, Immunology, and/ or Immuno-Oncology to join our rapidly growing Cell Therapy Team.  In this role you will make use of your in vivo and/ or in vitro experience in T cell immunology to contribute to the advancement of innovative Cell Therapy products by designing and conducting laboratory experiments, developing methodology, and generating and interpreting scientific data in a highly collaborative environment.

Accountabilities

• Conducts hands-on in vivo research including design, implementation, and interpretation of studies
• Conducts routine drug discovery research experiments by applying the techniques of molecular and cellular biology, analyzes and interprets data, and communicates results to team members
• Supports a team and works collaboratively with project managers to ensure the efficient relay of information and forward translation of data
• Assesses and reports data, with little or no guidance, in a clear and concise manner, while developing an understanding of its implications within the overall context of drug discovery
• Provides technical instruction to the team and allocates administrative work where possible
• Communicates and shares information between distinct projects within the bioscience function and across other functions as required
• Ensures own work, and work of peers, is compliant with Safety, Health and Environment standards and all other relevant internal AstraZeneca standards and external regulations

Essential

• PhD in a relevant discipline with 0-3 years of demonstrated experience in Cellular Therapy, Immunology, and/ or Immuno-Oncology
• Extensive in vivo skillset including animal handling, mouse tumour models, standard routes of dosing and engraftment, and tissue processing
• Experience with humanized mouse models and in vivo model development
• In vitro skillset with a well-developed understanding of molecular and cellular biology, immunological assays, cell transfection/ transduction, and advanced cell culture techniques
• Ability to design, execute, and troubleshoot experiments, and to review, analyze, and interpret results

Desirable

• Experience with genome editing technologies (CRISPR/ Cas9, base-editing, transposons, etc.)
• Multicolour flow cytometry expertise
• Basic experience developing cellular therapies including CAR-T/ CAR-NK, TCR-T, and/ or TIL therapies
• Experience with in vivo CAR-T therapies
• Experience working with human and/ or cyno T cells
• Experience with metabolic assays, such as nutrient uptake and Seahorse metabolic flux assays
• Computational biology experience and proficiency in Python and/or R, prior experience in UNIX-based systems, high-performance computing (e.g. SLURM), and large-scale data management
• Expertise in -omics technologies and data science (such as generating and analyzing single cell RNAseq and ATACseq datasets)
• Familiarity and experience with AI predictive modelling tools and statistical methods applied to training of machine learning models
• Background in drug discovery and development in the pharmaceutical industry

The annual base pay for this position ranges from $116,284.00 to 174,426.00. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility.

Join us in our unique and ambitious world.

Why AstraZeneca:

Here, courage, curiosity, and collaboration fuel a relentless focus on transforming cancer outcomes, powered by a pipeline that fuses cutting-edge science with advanced technology. You will work in an environment where unexpected teams come together to spark bold ideas, backed by meaningful investment and a clear path from discovery to impact. We value kindness alongside ambition, and we empower leaders at every level to ask sharp questions, take smart risks, and turn data into decisions that help patients sooner.

Date Posted

24-Feb-2026

Closing Date

25-Feb-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.