Senior/Principal Physician (CVRM)
AstraZeneca
Posted: March 13, 2026
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Quick Summary
A senior/principal physician with expertise in biological mechanisms and pharmacogenetics, collaborating with internal experts and external groups to design and execute studies. The ideal candidate will have strong communication and project management skills, with experience in clinical trials and epidemiological research.
Required Skills
Job Description
Typical Accountabilities:
• Reviews literature and consults with internal experts to identify biological mechanisms underlying pathophysiology and/or potential drug effects
• Assists in the design and execution of studies to assess biological mechanisms such as preparing pharmacogenetics components of clinical study protocols
• Liaises with colleagues in Clinical Pharmacology to assist in the design and execution of Phase I Clinical trials to establish Proof of Principle and to support Proof of Concept
• Initiates and monitors epidemiological research done by external scientific groups and provides medical/physician expertise to epidemiology colleagues who are not physicians
• Acts as a regional technical expert supporting the delivery of strategic input within the area of Physicians and provides consultancy within area of specialism
• Responsible for the safety evaluation in the early clinical trials, as well as the pharmacodynamic evaluation of the early compounds
• Delivers pharmacogenetics contribution to Translational Science Plans and Clinical Development Plans
• Supervises volunteers participating in medical trials and reviews safety assessments
• Leads the development of setting statistical standards or techniques in order that the quality, efficiency or effectiveness of projects are improved for overall Group efficiency
• Accountable for specialised research to enhance the effectiveness of Biostatistics contributions to worldwide submissions across a range of products
• Provides highly experienced strategic input, statistical expertise, and leadership to project teams in the design and interpretation of clinical studies and programmes of studies
• Applies expert physician skills to support internal proposal development and external regulatory submissions
• Acts as a source of knowledge in area of expertise, defining and communicating important initiatives across departments and functions
• Contributes to establishing and implementing policies, procedures and objectives for own work or team area to ensure compliance with both internal and external regulations
• Provides professional expertise to optimally design, analyse and interpret epidemiological studies and perform in depth epidemiological literature reviews
• Responsible for the safety evaluation in early clinical trials, as well as the proper pharmacodynamic evaluation of the early compounds
• Promotes good physician practice and ensures adherence with relevant protocols
• Develops operational systems and research processes across area of responsibility to increase the effectiveness and efficiency of projects
Typical People Management Responsibility (direct / indirect reports):
• Approximate number of people managed in total (all levels) - 10
• Matrix Manager – (projects/dotted line)
What is the global remit? (how many countries will the role operate in?):
• Own country
Education, Qualifications, Skills and Experience:
• Essential: Bacherlor’s degree in medicine; Thorough knowledge of study analysis and design in all phases of drug development; Experience of modelling and simulation to improve execution of studies
• Desirable: Extensive general medical knowledge
Key Relationship to reach solutions:
• Internal (to AZ or team): Members of all functions on project team; Members of Development
• External (to AZ): External service providers; External regulatory agencies
Date Posted
13-3月-2026
Closing Date
14-5月-2026
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.