Senior Pharmacometrician II - Focus on MIDD & QSP (all genders) - 18 months temporary, fulltime

Science is at the heart of what we do. People are at the heart of why we do it.

Welcome to AbbVie! As part of an international company with 50,000 employees worldwide and around 3,000 employees in Germany, you will have the opportunity of addressing some of tomorrows unmet medical needs in close collaboration with your colleagues. Are you passionate about improving global health care? Do you want to contribute to improving patients' quality of life through your expertise? In a challenging work environment that offers opportunities of developing and increasing your own skills? You’ve come to the right place!  

Pharmacometrics is focusing on the mathematical and statistical analyses and modeling of biological, pharmacological, and physiological data and processes. It quantifies the various aspects of the (desired and undesired) effects of drugs in the context of disease. The models are based on clinical data, and provide a basis for informing efficient drug development, regulatory decisions, and optimal treatment of patients. 

We are looking for a MIDD and QSP expert who will build and implement mechanistic models to support our platform modeling strategy in oncology development. You will propose modeling and simulation ideas within the MIDD framework and implement these efforts to drive our development programs forward. In this role, you will investigate, identify, develop, and optimize methods that enhance our MIDD strategy. Acting as the MIDD expert in oncology development, you will critically evaluate relevant developments in QSP, MIDD approaches, and regulatory requirements. You will integrate this knowledge into the Clinical Pharmacology MIDD strategy for both research and development programs, with a primary focus on oncology.

In detail this means you: 

• Develop QSP platform models for multiple oncology mechanisms
• Create and optimize Virtual Populations to capture patient heterogeneity and support clinical trial design
• Implement new methods to enhance QSP-driven MIDD, including AI/machine learning augmentation for literature screening, model drafting, and virtual population optimization
• Deliver practical results that inform dose and regimen selection, optimal combinations, therapy duration, and study design for active development programs
• Work as part of a coordinated team within the PMx Oncology Group

This is how you can make a difference:

• PhD with 0+, Master’s degree with 5+ years of experience in a field related to Applied Mathematics, System Pharmacology or comparable
• Interest in medical topics
• Proven scientific track record and practical experience such as successfully implemented QSP models, modeling with differential equations, scripting languages (R, Matlab, Python, Julia or similar) or clinical trials and drug development
• Critical and self-reflective thinker
• Persistence and resilience 
• Ability to connect unrelated concept and to generate original or unique ideas
• You influence colleagues to achieve departmental alignment
• You give full accountability when delegating and accepts full accountability when delegated to
• Fluency in English required, German would be a plus

Here's how we can move mountains together: 

• with a diverse work environment where you can have a real impact 
• with an open corporate culture 
• with an attractive salary 
• with an intensive onboarding process with a mentor at your side 
• with flexible work models for a healthy work-life balance 
• with a corporate health management that offers comprehensive health and exercise programs 
• with company social benefits 
• with a wide range of career opportunities in an international organization 
• with top-tier, attractive development opportunities 
• with a strong international network 

 

Multiple times, we have been globally recognized as a "Great Place to Work" and we are proud to provide our employees with the flexibility to maintain a healthy work-life balance. We take our impact on the environment and our communities seriously and therefore focus on giving something back on a regular basis. We are committed to equality, equity, diversity and inclusion (EED&I) – a commitment that is fundamental to us. This includes appreciating different perspectives, creating an inclusive culture and treating all employees with dignity and respect. 

At AbbVie, your individual contributions count – help us move mountains together. Be a part of our success, grow with us and accomplish more than you could have imagined. Sounds like the perfect career opportunity for you? We look forward to receiving your application! All you need is a complete CV – we will discuss everything else with you in person. 

Any questions? Feel free to email as at [email protected] – we look forward to hearing from you!

AbbVie setzt sich für Chancengleichheit ein und verpflichtet sich, mit Integrität zu arbeiten, Innovationen voranzutreiben, Leben zu verändern und unserer Gemeinschaft zu dienen. Chancengleichheit bei Arbeitgeber/Veteranen/Behinderten.