Senior Medical Science Liaison (MSL) - Field/HQ Hybrid Role

Role Summary

This Senior Medical Science Liaison (MSL) role is a unique opportunity for an individual to impactfully contribute to both key field-based and HQ Medical Affairs initiatives.

As the first Medical Science Liaison, this individual will play a pivotal role in shaping the scientific landscape for Lexeo Therapeutics’ clinical gene therapy programs by being a strategic, field-based extension of the Medical Affairs team.

This position offers meaningful exposure to headquarters-based functions and strategic initiatives within a growing biotech organization. The individual in this role will help build foundational elements of Lexeo’s field medical organization, including shaping the therapeutic area landscape for gene therapy launch readiness and helping to build a field medical function aligned with quality, depth, and scientific impact rather than traditional quantitative metrics.

This expanded scope enables personal and professional growth beyond the conventional field medical remit and will allow the individual to lead Medical Affairs workstreams that collaborate with cross-functional teams and involve Lexeo leadership.

This individual would be joining Lexeo during an expansion phase and an exciting time, offering an opportunity for professional development and advancement.

This is a hybrid role; travel will be required for the field-facing aspect of this role and to the NYHQ office as necessary.

Desired Candidate Profile

In addition to the required qualifications listed below for this role, we are seeking a team member who is highly motivated and has a proactive approach to their work. An individual who thinks outside the box, is solution-driven, open and adaptable to change, and wants to meaningfully contribute to shaping Medical Affairs function at Lexeo will thrive in this role!

If this sounds like you, we welcome you to apply!

Primary Responsibilities:
• Leverage scientific expertise to establish and maintain strategically impactful relationships with national, regional, and local Key Opinion Leaders (KOLs) and other healthcare providers (HCPs) for Lexeo’s cardiac gene therapy pipeline, in alignment with medical strategy
• Proactively and reactively engage KOLs and HCPs on various topics, including disease state education, mechanism of action, emerging and existing clinical data, and the evolution of treatment landscapes for Lexeo’s cardiac gene therapy pipeline
• Support asset-specific pre-launch readiness and optimize launch execution through the attainment of impactful field medical metrics
• Provide internal stakeholders with actionable medical insights gathered from scientific interactions with HCPs
• Explore new areas of scientific and clinical interest to understand unmet needs, how the landscape is evolving, and how Lexeo’s pipeline programs may address those needs
• Collaborate with Clinical Development and Clinical Operations to support clinical trial sites and investigators as needed
• Stay current on medical and scientific developments in related therapeutic areas by continuously reviewing literature, monitoring competitor activities, networking with experts, and attending assigned scientific congresses and symposia
• Complete accurate and timely administrative responsibilities, including reports, projects, and required documentation
• Deliver approved medical and scientific presentations to internal and external stakeholders
• Support evidence generation efforts by facilitating external investigator-sponsored research (ISR) concept submissions
• Regularly collaborate with field-based and cross-functional colleagues to advance clinical practice in a compliant manner
• Support medical and scientific training of cross-functional teams as needed
• Adhere to Lexeo Therapeutics’ values, culture, and policies.

Required Skills and Qualifications:
• MD, DO, PhD, PharmD, other doctorate degrees relevant to the role, RPh, NP, PA, other APPs, and/or a Master’s degree in life sciences with clinical research experience in neuromuscular or cardiac disease
• 3+ years of field experience in the biotech or pharmaceutical industry, OR 2+ years and launch experience, OR direct patient care experience in cardiology or neurology
• Gene therapy experience preferred, particularly in the neuromuscular space
• Ability to interpret key scientific data and translate findings to meet educational and research needs
• Strong interpersonal, presentation, and communication skills, and demonstrated ability to work collaboratively in a dynamic, fast-paced, team-oriented environment

About Lexeo

Lexeo Therapeutics is a clinical-stage genetic medicine company headquartered in New York City, pioneering cardiac genetic medicine candidates to treat the root causes of inherited cardiovascular diseases. Our lead program, LX2006, targets cardiomyopathy associated with Friedreich’s Ataxia and anchors a broader pipeline addressing genetically defined conditions such as hypertrophic and arrhythmogenic cardiomyopathies. Backed by a strong financial foundation, Lexeo is positioned to translate groundbreaking science into durable clinical impact.

Our work culture is a hybrid model with 2 days/week in the New York City office and 3 days working from home.

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.