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Senior Manager, Clinical Outsourcing & Vendor Management

Tangotherapeutics

Boston, MA (201 Brookline Avenue, Suite 901, Boston, MA) permanent

Posted: January 26, 2026

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Quick Summary

Senior Manager, Clinical Outsourcing & Vendor Management

Job Description

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts

Summary

Tango has an exciting new opportunity to join our organization as a Senior Manager, Clinical Outsourcing and Vendor Management. This position reports to the Senior Director, Outsourcing and Vendor Management and is responsible for overseeing and facilitating the outsourcing of services and management of external vendors to ensure the successful execution of clinical trials. You will partner with clinical project teams and cross-functional leadership to assess key vendors and optimize outsourcing strategies, vendor selection, and relationship management for Tango’s needs. The Senior Manager plays a critical role in ensuring that outsourced clinical activities meet organizational goals, regulatory requirements, timelines, and quality standards.

Your Role:

• Provide primary outsourcing and vendor management support for functional areas supporting clinical trials within Tango, ensuring alignment with study and organizational objectives

• Interact closely with cross-functional teams to identify and meet outsourcing and contracting needs for clinical vendors, including CROs, laboratories, and specialty providers

• Lead the vendor identification, assessment, and selection process for outsourced services, including preparing and managing requests for proposals, coordinating cross-functional review and assessment, and conducting budget analysis and negotiation

• Identify and promote cost-saving opportunities and spend conservation through close monitoring of out-of-scope cost adjustments with vendors and detailed review and negotiation of contracted budgets and change orders. Foster strong relationships with key vendors to achieve better pricing and more favorable payment terms. Ensure that all out-of-scope costs are properly authorized by relevant stakeholders and documented comprehensively

• Together with key team members, ensure vendor adherence to contract or individual scope of work throughout life of study

• Monitor and analyze vendor performance trends across individual functions and across multiple projects/programs

• Contribute to the development and optimization of process, tools, and templates to improve overall outsourcing and vendor management practices. Train internal teams on best practices and new procedures

• Build and maintain strong, collaborative relationships with external vendors and internal stakeholders on clinical programs, serving as primary point of contact for vendors and supporting project teams in the resolution of vendor performance issues

• Additional duties and responsibilities as required

What You Bring:

• Bachelor’s Degree in life sciences, business, or related field · Minimum of 7 years’ experience in clinical operations, outsourcing, procurement, or vendor management within the pharmaceutical, biotechnology, or CRO industry; equivalent combination of education and experience considered

• Proven experience managing clinical vendors and outsourcing activities for clinical trials

• Track record of establishing effective business relationships with internal and external customers

• Experience with vendor management best practices

• Strong knowledge of GCP, ICH guidelines, and relevant regulatory requirements

• Excellent negotiation, communication, and interpersonal skills

• Demonstrated ability to manage multiple projects and priorities in a fast-paced environment while remaining flexible, proactive, resourceful, and efficient

• Proficiency in MS Office Suite and collaboration platforms such as Sharepoint or Egnyte; experience with contract management systems a plus

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Salary range
$143,200—$214,800 USD

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