Senior Manager - Chemical R&D (Peptide)

At TAPI, we’re not just a company—we’re a community committed to advancing health from the core. As the world’s leading supplier of active pharmaceutical ingredients (APIs), we partner with 80% of the top 50 global pharmaceutical companies. With a legacy spanning over 80 years and a portfolio of more than 350 products, as well as custom CDMO services, we’re shaping the future of health worldwide.

Our strength lies in our people—a team of over 4,200 professionals across 13 state-of-the-art facilities in Italy, Hungary, the Czech Republic, Croatia, Israel, Mexico, and India. Together, we innovate, solve problems, and deliver excellence. Join us and be part of a mission that transforms lives.

Are you a passionate Team Leader with a strong background in organic chemistry and peptide synthesis? Do you thrive in a fast-paced, research-driven environment where innovation meets impact? Join our cutting-edge Global R&D Centre, where your expertise will drive the development of life-changing therapies!

🌟 Key Responsibilities – What You’ll Be Doing:

• Design and Execution: 

• Design and execute synthetic routes for novel or complex peptides using techniques like Solid Phase Peptide Synthesis (SPPS) and Liquid Phase Peptide Synthesis (LPPS).
• Experience in handling automatic peptide synthesizer, Prep HPLC, Lyophilizer & other related instruments.

• Process Optimization & Scale-Up: Optimize existing peptide synthesis processes to improve efficiency, yield, and purity, and facilitate the scale-up of processes from lab to manufacturing/GMP scale.
• Impurities: hands-on experience in preparation and characterization of impurities in peptide molecules.
• Analysis and Characterization: Oversee and interpret analytical data from techniques such as HPLC, LC-MS, MALDI-TOF, and NMR to confirm product identity and purity.
• Troubleshooting: Identify and resolve technical or synthetic challenges that arise during projects.
• Innovation: Stay current with the latest developments in peptide chemistry, including automation and computational methods (e.g., AI/ML in design), and integrate innovative solutions into workflows. 
• Project Coordination: Manage project timelines, budgets, and resources effectively, ensuring projects are delivered on time and within scope.
• Collaboration: Work closely with cross-functional teams (e.g., analytical chemistry, technology transfer and manufacturing) to meet project goals.
• Documentation and Compliance: Ensure all experimental work and data are accurately documented (often in eLN - electronic laboratory notebooks) and that operations comply with safety, Good Laboratory Practice (GLP), and Good Manufacturing Practice (GMP) standards.
• Communication: Act as a primary technical contact for clients and internal stakeholders, providing regular updates and detailed scientific reports. 
• Reports: To prepare and review reports such as safety, vendor qualification reports, process development, ACMI report, Nitrosamine assessment for customers 
• Creativity: Contribute novel ideas by participating during technical discussion & motivating the team members
• EHS: To meet EHS expectations and guiding other members 
• Presentations and Reviews: Preparation and sharing presentations for various reviews with internal and external customers.
• Proactiveness: Proactively advise and share knowledge and expert opinions with subordinates, peers, and senior management. Mentor staff in troubleshooting strategic and experimental issues.
• Stake holder management: The position involves multi-disciplinary interactions with organic chemists, analytical chemists, engineers, IP, Regulatory and program management. 
• Continuous improvement: The candidate will identify and nurture ideas for continuous improvement activities and initiatives within the department.

 🌟 Technical Competencies:

• Focus on peptide synthesis, literature search, developing and analyzing peptides (using LC-MS, and NMR), and its characterization.
• Must have handled Peptide Synthesizers (Manual/Automatic), Purification Using Preparative HPLC, Lyophilizer and must be aware about Membrane filtration process.
• Broader scope including technology development, cross-functional collaboration, and process optimization. 

      We’re looking for candidates with a strong academic background and hands-on industry experience in organic chemistry and process development. The ideal candidate will have:

• M.Sc. in Organic Chemistry with 12 years of relevant industrial experience

OR
• Ph.D. in Chemistry with at least 10 years of experience.

   In addition to academic credentials, we value:

• Sound knowledge of Peptide synthesis, organic chemistry, Spectroscopy, Drug Regulatory Affairs & Quality Assurance
• Experience in handling automatic peptide synthesizer, Prep HPLC. Lyophilizer
•  ICH Guidelines and IP understanding
• Good experimental hand & Scale-up knowledge
• Innovative thinking & excellent observance
• Problem Solving Ability
• Excellent teamwork and collaboration within & with other functions
• Effective communication & Presentation skills
• Planning & Organization

Make Your Mark with TAPI

Your journey with TAPI is more than a job—it’s an opportunity to make a lasting impact on global health. If you’re ready to lead, innovate, and inspire, we’re excited to welcome you to our team. Together, let’s shape the future of pharmaceuticals. Apply on top of this page and our talent acquisition team will be in touch soon!