Senior Director, Pricing and Contracting

“Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit https://mineralystx.com. Follow Mineralys on LinkedIn, Twitter and Bluesky”

Mineralys is a fully remote company.

As a key member of the Market Access leadership team, The Senior Director, Pricing and Contracting is a critical strategic and operational role responsible for developing and executing Mineralys' contracting and pricing strategy as the company approaches its first commercial product launch. This individual will serve as the company's subject matter expert on all aspects of pricing, contracting, gross-to-net (GTN) management, pricing reporting systems and government pricing compliance, and will play a central role in ensuring that Mineralys achieves strong market access and revenue optimization at launch.

The Senior Director will lead contract development and negotiation across a broad range of customer segments while also overseeing the company's government pricing program and serving as a key member of the Pricing Governance Committee. This individual will work closely with senior leadership, Market Access, Commercial, Finance, Trade and Distribution, Legal, and Patient Services.

Key Responsibilities

Pricing Strategy and Governance

• Serve as a core member of the Pricing Governance Committee, partnering with the SVP, Market Access, CFO, and senior leadership to evaluate and approve pricing decisions, rebate strategies, and contract terms for key customers.

• Lead ongoing competitive pricing analysis and market intelligence, monitoring competitor pricing, payer dynamics, and industry trends to inform Mineralys' pricing strategy and enable proactive responses to market developments.

• Develop and maintain GTN forecasting models in collaboration with Finance; ensure accurate accrual estimates and provide regular reporting to support financial planning and compliance.

• Assess and advise senior leadership on the benefit/risk implications of complex pricing and contracting decisions, highlighting customer impacts, policy risks, and operational considerations.

Contract Development and Negotiation

• Develop contract templates, standard language, and contracting frameworks for all customer segments, including GPOs, PBMs, health plans andmanaged Medicaid,

• Negotiate and execute market access agreements with key customers, managing the full contract lifecycle from initial bid through execution, ensuring terms protect the organization from unintended liabilities and align with business objectives.

• Work closely with Market Access account executives to support bids and customer negotiations, providing pricing and contract expertise while maintaining appropriate internal firewall protocols.

• Ensure all contracts are aligned with strategic business objectives, relevant regulations, and internal policies; manage contract compliance and identify and address revenue leakage.

• Support the RFP and selection process for specialty pharmacies and distributors in partnership with the Trade and Distribution team.

Government Pricing and Compliance

• Oversee all government pricing obligations, including AMP, Best Price, ASP, and Medicaid rebate calculations, ensuring accurate and timely reporting in compliance with applicable federal and state regulations.

• Manage the company's relationship with its government pricing vendor (Integrichain), overseeing program setup, ongoing operations, audit readiness, and compliance with all reporting obligations.

• Assess all administrative and service fees for bona fide service requirements and fair market value to ensure appropriate treatment in government pricing calculations.

• Stay current on evolving government regulations, legal rulings, and industry guidance; advise leadership on implications for contractual and reporting obligations.

Cross-Functional Collaboration and Operations

• Partner cross-functionally with Market Access, Commercial, Finance, Legal, Trade and Distribution,, and senior leadership to align contracting strategy with corporate objectives.

• Streamline contracting and pricing operations; develop and maintain policies, procedures, and decision frameworks to support scalable, compliant, and efficient processes.

• Support analytics related to contract performance, GTN variances, and pricing trends; translate data into actionable insights for leadership.

• Contribute to launch readiness planning, ensuring all contracting, pricing, and government pricing infrastructure is in place prior to commercial launch.

Qualifications

• 10+ years of progressive experience in pharmaceutical pricing and contracting, with substantial experience in a senior individual contributor or director-level role.

• Deep expertise across the full contracting lifecycle with payers, GPOs,PBMs and Health plans..

• Hands-on government pricing experience, including AMP, Best Price, ASP, and Medicaid rebate calculations, and familiarity with relevant federal and state compliance requirements.

• Strong GTN modeling and forecasting capabilities; experience collaborating with Finance on accruals and financial reporting.

• Demonstrated ability to develop contract strategy, negotiate with major payers and PBMs,.

• Proven ability to operate effectively in a small company environment, managing both strategic direction and hands-on execution.

• Bachelor's degree required.

Travel

• This position requires up to 20% travel. Frequently travel is outside the local area and overnight. Some of the travel may be international.

Position eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level.

US Salary Range: $245,000 - $260,000

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