Senior Director, Medical Affairs

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

Tango Therapeutics is seeking a Senior Director of Medical Affairs to support our lead oncology program as it enters its first pivotal study. Reporting to the SVP, Head of Clinical Development, this role is centered on hands-on Medical Affairs execution; overseeing key vendors, managing budgets and timelines, and ensuring high-quality deliverables across medical information, field operations, and evidence-generation partners.

You will lead a global MSL team, driving consistent field engagement, supporting site activation and accrual, and ensuring alignment with clinical development priorities. The role also includes coordinating patient advocacy efforts and maintaining strong cross-functional communication to support late-stage development and prepare for future commercialization.

Your Role

• Manage MSL vendor(s), defining scope, coverage, and performance expectations

• Provides strategic and operational leadership to a global MSL team, fostering alignment, collaboration, and high-quality scientific exchange across diverse regions and healthcare systems

• Provide scientific training through quarterly sessions and ongoing data updates

• Monitor MSL activities, KOL engagement quality, and field insights; translate findings into strategic recommendations

• Direct MSL priorities for investigator education and enrollment acceleration at underperforming sites

• Map priority KOLs by region with specific engagement objectives for MSL execution

• Manage advisory boards to gather insights and validate strategy

• Develop publication plans with journal targets, authors, and timelines

• Create compliant medical education materials (slide decks, data summaries, FAQs) for MSL field use

• Represent Tango at 4-6 major congresses annually

• Build patient advocacy function through partner identification and engagement planning

• Partner with Clinical Operations on site strategy and investigator support

• Comfortable with frequent travel to build strong relationships with KOLs and actively participate in scientific meetings and major industry conferences

What You Bring

• MD, PhD, or equivalent advanced scientific degree

• Minimum of 10 years of experience in Medical Affairs within biotech/pharma

• Deep expertise in oncology and strong experience in late-stage clinical development and product launch preparation

• Experience in building and leading high-performing Medical Affairs teams, including MSLs and vendor management

• Knowledge of applicable global regulatory and compliance frameworks (FDA, EMA, GCP, ICH)

• Strong network of Oncology KOLs, health authorities, and scientific organizations, and demonstrated success in engaging these stakeholders

• Ability to travel regularly to our Boston headquarters

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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