Senior Director, LCM Program Management

“Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit https://mineralystx.com. Follow Mineralys on LinkedIn, Twitter and Bluesky”

Mineralys is a fully remote company.

Senior Director, Life Cycle Management (LCM) Program Management

The Senior Director, Life Cycle Management (LCM) Program Management is a strategic leadership role responsible for governing and driving the end-to-end life cycle management strategy for the lorundrostat program. This leader partners closely with Clinical Development, Regulatory, CMC, Commercial, Medical Affairs, Finance, and Corporate Leadership to ensure that life cycle opportunities are prioritized, and executed.

The Senior Director serves as the enterprise LCM orchestrator, translating Corporate strategy into integrated, executable life cycle plans, establishing fit-for‑-‑purpose governance, and enabling data-driven decision making at the GPT and Executive levels. This role requires comfort operating in ambiguity, influencing without authority, and balancing near-term execution with long-term value creation in a rapidly evolving setting.

Principal Responsibilities

• Serve as the Program Management Lead for life cycle initiatives, coordinating cross-functional teams across Clinical Development, Regulatory, CMC, Commercial, Medical Affairs, Market Access, Safety, Quality, and Operations.

• Evaluate, and prioritize life cycle opportunities, risks, and trade-offs aligned with corporate strategy and value creation goals.

• Drive alignment on objectives, scope, timelines, dependencies, and critical path activities across life cycle workstreams.

• Facilitate and lead cross-functional forums, life cycle reviews, and governance discussions to enable timely, well-informed decision making.

• Develop high-quality executive-level materials, dashboards, and decision frameworks that synthesize complex cross-functional inputs.

Skills and Attributes

• Collaborative leader who can align diverse stakeholders toward common goals

• Strategic and systems thinking with a portfolio mindset

• Executive presence and exceptional communication skills

• Ability to translate strategy into actionable, integrated plans and pivot, re-evaluate as needed

• Strong risk management, scenario planning, and problem-solving capabilities

• Ability to work under time pressure and effectively in a team or matrix environment

• Metrics-oriented, execution that delivers value and moves the business

Education and Experience

• Bachelor’s degree required; advanced degree (MBA, MS, MD, PhD) preferred.

• Extensive experience in program and portfolio management within biopharmaceutical or life sciences organizations.

• Demonstrated leadership across full product life cycle, including launch, and post approval optimization.

• Proven ability to operate at the enterprise and executive level, influencing strategy and decisions across functions.

• Strong track record of leading complex, cross-functional initiatives in fast paced, ambiguous environments.

Travel

• This position requires up to 10% travel. Frequently travel is outside the local area and overnight. Some of the travel may be international.

Position eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level.

US Salary Range: $225,000 - $250,000

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