Scientist, Radiochemistry

Actithera is a radiopharmaceutical biotech company, co-headquartered in Oslo and Cambridge, Massachusetts, founded in 2021. The company applies a chemistry-first approach to design next-generation radioligand therapies (RLTs) that deliver potent, tumor-focused radiation while sparing healthy tissue—guided by an isotope-agnostic and platform-enabled strategy to optimize tumor retention and therapeutic index. Actithera’s vision is rooted in precision molecular design and a deeply collaborative culture, with a shared mission to transform the lives of cancer patients through innovative science.

We are seeking a motivated and skilled Scientist in Radiochemistry to join our R&D team in Oslo. The Scientist will work hands-on in the laboratory under the guidance of a Senior Scientist, supporting radiochemistry, analytical development, and CMC activities across discovery, preclinical, and early clinical programs. This role is well suited for a scientist looking to grow expertise in radiopharmaceutical development within a highly collaborative environment.

Key Responsibilities

Prepare radiolabeled compounds for in vitro, in vivo, and ex vivo studies, coordinating closely with the pharmacology team.

Execute radiolabeling experiments for small molecules and other targeting vectors using clinically relevant radionuclides (e.g. Lu-177, Ac-225, In-111, or others as appropriate), following established protocols and SOPs.

Support development and optimization of analytical methods for radiopharmaceutical drug products, including radio-HPLC and iTLC, under supervision.

Perform routine radiochemical and analytical testing, including sample preparation, data acquisition, and data analysis.

Assist in method troubleshooting and robustness testing, including investigation of impurity profiles, stability trends, and formulation-related effects.

Support CMC development activities, including execution of laboratory experiments and generation of data for IND/CTA-enabling packages.

Assist with technology transfer activities, including preparation of experimental data, protocols, and supporting documentation for internal teams or external CDMOs.

Provide hands-on support for clinical manufacturing activities.

Ability to multi-task different projects and manage time effectively.

Maintain accurate and compliant laboratory documentation, including lab notebooks, batch records, and raw data files.

Collaborate with colleagues across radiochemistry, pharmacology, QA, and CMC to support project timelines and deliverables.

Ensure compliance with radiation safety regulations, GMP-relevant procedures (as applicable), and internal SOPs, contributing to a safe and compliant laboratory environment.

Qualifications

MSc or PhD in chemistry, radiochemistry, pharmaceutical sciences, or a related discipline.

Hands-on experience with radiochemistry, radiolabeling, or handling of radioactive materials.

Experience with analytical techniques such as radio-HPLC and iTLC.

Exposure to, or strong interest in, CMC development and clinical manufacturing of radiopharmaceuticals.

Ability to follow established procedures while contributing to method optimization and continuous improvement.

Strong organizational skills, attention to detail, and commitment to data integrity.

Demonstrated ability to work effectively in a team-oriented, multidisciplinary environment.

What We Offer

Opportunity to work at the forefront of radioligand therapeutic discovery and clinical translation with a team committed to scientific excellence and patient impact.

Competitive compensation and benefits package.