Scientist, In Vivo Pharmacology

Job Title: Scientist, In Vivo Pharmacology

Location: Hamilton, Ontario

Onsite 5 days/week

Fusion Pharmaceuticals, a member of the AstraZeneca Group, is a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines.  Fusion connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumors.  Fusion’s clinical portfolio includes:  FPI-2265 targeting prostate specific membrane antigen (PSMA) for metastatic castration resistant prostate cancer currently in a Phase 2 trial;  FPI-1434 targeting insulin-like growth factor 1 receptor currently in a Phase 1 trial;  FPI-2059, a small molecule targeting neurotensin receptor 1 (NTSR1), currently in a Phase 1 trial; and FPI-2068, a bispecific IgG-based EGFR-cMET targeted radioconjugate currently in a Phase 1 trial.  In addition, Fusion is pursuing combination programs between RCs and DNA Damage Response Inhibitors (DDRis) and immune-oncology agents. Fusion has a fully operational Good Manufacturing Practice (GMP) compliant state-of-the-art radiopharmaceutical manufacturing facility to meet supply demand for Fusion's growing pipeline of RCs. 

Introduction to role:

Are you ready to turn radiopharmaceutical science into data that changes treatment decisions for patients? In this role, you will shape the next generation of targeted cancer radiotherapies by designing and executing in vivo studies that directly inform program strategy, dose selection, and advancement to the clinic.

You will join a collaborative, inquisitive team that pairs deep biological insight with innovative methodologies—bringing together novel biomarkers, quantitative readouts, and bold trial design thinking. How will you build an in vivo strategy that reveals mechanism, predicts efficacy, and accelerates breakthroughs for people living with cancer?

Accountabilities:
Study Design and Execution: Design, plan, and conduct mechanism-of-action, therapeutic efficacy, and biodistribution studies on radiopharmaceuticals in rodent models across cancer and other relevant disease indications to generate decision-ready data.
In Vivo Operations: Spend hands-on time in the lab and vivarium executing studies, including cell culture, in-life monitoring, blood sampling, dosing, and coordinated sample collection, ensuring high-quality data and animal welfare.
Ex Vivo Analysis: Perform and interpret IHC, autoradiography, flow cytometry, and biochemical assays to quantify target engagement, distribution, and pharmacodynamic effects.
Model Innovation: Implement new pharmacology models, technologies, and strategies to advance targeted cancer radiotherapies and expand translational capabilities.
Cross-functional Collaboration: Partner with diverse teams to provide scientific input; design, execute, and interpret studies; and deliver solution-oriented expertise that supports key decision-making.
Data and Documentation: Write and review study protocols and reports; analyze results; present findings to stakeholders; and contribute to manuscripts and regulatory filings that progress programs.
Compliance and Safety: Work safely and in full alignment with radioactive, biohazardous, and animal ethics regulations and guidelines, setting a high standard for responsible research.
Scientific Culture: Foster an environment of collaboration, scientific excellence, open exchange, and rigorous methodology that elevates team performance.

Essential Skills/Experience:
Proven experience designing, planning, and conducting in vivo pharmacology studies in rodent models, including mechanism-of-action, therapeutic efficacy, and biodistribution for radiopharmaceuticals.
Hands-on proficiency in lab and vivarium procedures: cell culture, in-life monitoring, blood sampling, dosing, and coordinated study execution.
Expertise with ex vivo analytical techniques such as immunohistochemistry, autoradiography, flow cytometry, and biochemical assays, with the ability to interpret complex data sets.
Demonstrated ability to collaborate across functions to design, execute, and interpret studies and provide solution-oriented scientific input for decisions.
Strong scientific writing and communication skills for study documentation, results analysis, presentations, and contributions to manuscripts and regulatory filings.
Track record of working safely and compliantly with radioactive materials, biohazards, and animal ethics standards.
Commitment to collaboration, scientific excellence, open scientific exchange, and deep scientific rigor.

Desirable Skills/Experience:
Experience implementing novel pharmacology models, technologies, and strategies specifically for targeted cancer radiotherapies.
Breadth of experience across cancer and additional disease indications relevant to radiopharmaceutical development.
Proficiency in quantitative biodistribution analysis and interpretation to link exposure, mechanism, and efficacy.
Experience contributing to regulatory filings for radiopharmaceutical programs.
Ability to influence decision-making through clear, solution-focused data narratives to diverse stakeholders.

Why AstraZeneca:
At AstraZeneca, you will work where bold science meets practical impact—sitting alongside imaging specialists, clinicians, data scientists, and biologists to challenge assumptions and move at pace. Our pipeline is fueled by unparalleled data and an interdisciplinary approach that blends novel biomarkers, AI-enabled insights, and innovative endpoints to reimagine how cancer is treated. We value kindness alongside ambition and empower people to take smart risks, learn quickly, and see their ideas translate into real options for patients worldwide.

SO, WHAT’S NEXT?

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

Recognizing the importance of individualized flexibility, our ways of working allow employees to balance personal and work commitments while ensuring we continue to create a strong culture of collaboration and teamwork by engaging face-to-face in our offices 3 days a week. Our head office is purposely designed with collaboration in mind, providing space where teams can come together to strategize, brainstorm and connect on key projects.

Great People want to Work with us! Find out why:

• GTAA Top Employer Award for 11 years
• Top 100 Employers Award
• Canada’s Most Admired Corporate Culture
• Learn more about working with us in Canada
• View our YouTube channel

Are you interested in working at AZ, apply today!

AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment, assessment and selection process and may be requested by emailing [email protected].

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Annual base salary for this position ranges from 82,377.60 to 108,120.60.AstraZeneca is committed to providing fair and equitable compensation opportunities to all colleagues. Our compensation policies and practices have been designed to allow colleagues to progress through the salary range over time as they progress in their role. The range provided in this posting represents an offer pay range used in a majority of situations. The base pay offered will vary depending on multiple individualized factors, including the candidate's skills and experience, job-related knowledge, and other specific business and organizational needs.  In some cases, offers outside the range may also be considered to address unique circumstances.

In addition, our permanent positions offer an annual Variable Pay Bonus/Short Term Incentive opportunity as well as eligibility to participate in our equity-based long-term incentive program (if applicable to role).  Benefits offered for permanent roles include a competitive Flex Benefits & Retirement Savings Program, 4 weeks’ paid vacation, and annual Personal Days. Fixed Term Contract/Temporary positions (excluding students) are offered a Contract Benefits Program.

We are using AI as part of the recruitment process.

This advertisement relates to a current vacancy.