Scientist, In Vivo Biology

Company Summary:

FL106 Inc., is a privately held, early-stage biotechnology company focused on developing novel drug delivery modalities. FL106 is backed by Flagship Pioneering, bringing the vision and resources to guide FL106 from platform validation to real-world solutions that meaningfully improve patient care.

Position Summary

FL106 is seeking a highly motivated Scientist for In Vivo & Translational biology to lead the design and execution of rigorous in vivo and ex vivo assays in support of novel drug delivery technologies. This role will be central to evaluating delivery performance, biodistribution, and biological activity across relevant model systems.

The ideal candidate is an independent, goal-oriented scientist with strong experimental dexterity and judgment, excellent communication skills, and a bias toward execution. You will work in a highly dynamic, fast-paced, and collaborative entrepreneurial environment, contributing directly to scientific strategy and data-driven decision-making. This is a unique opportunity to help build an early-stage biotechnology company and shape the next frontier of drug delivery.

Core Responsibilities

• Design, plan and execute mouse and rat studies, including experimental design, protocol development, dosing, tissue collection and processing, and data analysis to evaluate delivery technologies

• Perform readout assays such as flow cytometry, immunofluorescence imaging, bioluminescence, qPCR, and histology

• Manage and collaborate with CROs and external partners to ensure high-quality execution of outsourced studies

• Work closely with interdisciplinary team members (e.g., chemistry, engineering, formulation) to develop integrated experimental plans

• Contribute to the development and refinement of translational and preclinical scientific strategy

• Clearly communicate experimental results and insights through concise presentations, written summaries, and thorough documentation in an electronic lab notebook (ELN)

• Stay current with relevant scientific literature and emerging technologies, proactively sharing insights with the broader team

Qualifications and Skills

• PhD in Biology, Cell Biology, Immunology, or a related field

• 2+ years of experience in the biopharmaceutical or biotechnology industry preferred

• Extensive hands-on experience with in vivo biology in small rodents (mice required; rats preferred)

• Proficiency in high-throughput animal handling, injection techniques, and tissue harvesting and processing (IV, subcutaneous required other routes of administration – e.g. IM, IVT, IT, preferred)

• Experience with non-invasive in vivo imaging technologies, including bioluminescence and fluorescence imaging, strongly preferred

• Experience performing whole-body perfusion,single cell organ digestion, and cell sorting strongly preferred

• Proven expertise in protein and/or nucleic acid (DNA/RNA) isolation from mammalian cells and tissues, cDNA synthesis, and qPCR

• Experience with histological techniques, including tissue preparation, staining and data analysis

• Hands-on experience with flow cytometry, including sample preparation, panel design or execution, data acquisition, and downstream analysis, strongly preferred

• Proven ability to develop, optimize, and troubleshoot biological assays

• Strong organizational and planning skills, with attention to experimental rigor and reproducibility

About Flagship

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in generation of over 500 patents, initiation of over 50 clinical trials for novel therapeutic agents and an aggregate value of more than $90 billion. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $100,000 - $143,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL106 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL106's good faith estimate as of the date of publication and may be modified in the future.