Scientist I/II, In Vitro Pharmacology

About Hexagon Bio:

Hexagon Bio leverages a genomics-based platform and understanding of natural product evolution to develop next-generation antibody drug conjugates (ADCs) with novel payloads for cancer. We use data science, genomics, machine learning, synthetic biology, and automation to discover potent, evolutionarily refined small molecules from microbial genomes, and apply medicinal chemistry to optimize these molecules into truly transformative medicines.

Location: Menlo Park, CA

Job description:

Hexagon Bio is seeking a highly skilled Scientist, In Vitro Pharmacology to support the development and characterization of next-generation ADCs featuring novel natural-product payloads. This is a hands-on, laboratory-based position where you will design and execute in vitro cell-based assays critical to profiling ADC properties informing safety and efficacy: binding, internalization, trafficking, receptor profiling, potency and death pathway screening, and functional studies.

You will collaborate closely with chemists, biochemists, and other cell biologists to accelerate the evaluation of new payloads, linkers, and ADC conjugates. The ideal candidate brings a strong foundation in cancer cell biology, high-quality in vitro and ex-vivo assay expertise, in vivo study experience, and a demonstrated ability to think critically, multi-task, troubleshoot assays, and interpret data.

We seek innovative and collaborative team members who thrive in fast-paced environments and are motivated by our mission to transform cancer therapeutics.

Key Responsibilities:

• Design and execute in vitro assays to evaluate activity and potency (safety and efficacy) of ADCs with novel natural product payloads.

• Execute specialized ADC assays in drug treated cells and ex vivo tissues: binding, internalization, trafficking, receptor profiling, potency and death pathway screening, IHC, and functional studies.

• Support in vitro to in vivo translation studies using multi-color flow cytometry assays

• Evaluate emerging technologies (e.g., organoids, organ-on-chip) and develop new assays to expand capabilities.

• Analyze and interpret experimental data to guide project decisions.

• Collaborate with multidisciplinary teams to support candidate selection and robust lead candidate data packages.

• Excellent written and oral communication skills to present findings to project teams and senior leadership.

• Maintain detailed electronic laboratory notebooks.

• Ensure compliance with safety policies and best laboratory practices.

• Contribute to a team culture of scientific rigor, transparency, and innovation.

Requirements:

• PhD in Cell Biology, Cancer Biology, Molecular Biology, or a related field.

• 1-3+ years of hands-on biotech/pharma experience.

• Proven expertise in complex mammalian cell culture, including cancer cell lines and primary cells (familiarity with 3D assays or organoids is a plus).

• Proficiency with multicolor flow cytometry (sample prep, compensation, gating, analysis).

• At least 1 year hands-on mouse tumor models and in vivo pharmacology experience complementing in vitro assay expertise.

• Experience supporting ADCs, or targeted oncology programs, is a bonus

• Experience using Microsoft Word, Excel, and PowerPoint as well as GraphPad Prism and FlowJo software.

• Strong analytical and troubleshooting ability.

• Excellent organizational, communication, and documentation skills.

• Ability to work independently and in cross-functional teams.

• Initiative, creativity, and ability to thrive in a fast-paced startup environment.

What We Offer:

• A flexible and dynamic work environment where you pave your own path, Hexagon cultivates employees' unique strengths at all levels and provides mobility across departments.

• “All Hands Meetings” provide an opportunity to share company and team updates. These meetings are rooted in our value of transparency. They are designed to foster a culture of collaboration, curiosity, and open communication.

• Rapid career advancement for driven performers.

• Access to scientific conferences throughout the year.

• A range of amenities, courtesy of the Menlo Park Labs business park, including shuttle, gym, rock-climbing wall, pool, sauna, sports courts, cafe, bike lockers, and free EV charging stations.

• Opportunities to engage with the Hexagon community through team-building events like our Hexagon Happy Hours and holiday parties.

Additional Information:

The salary range is dependent on the level of Scientist that is hired. The salary range for this position is $120,000 - $160,000. Our salary ranges are determined by role, level, and location. The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across California locations. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training.

Hexagon Bio is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, disability status, membership in an organization, or any other non-merit factors

Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.