Scientist, Early CVRM

Scientist, Early CVRM

About the Role

We are seeking a highly motivated Scientist to join the Metabolism Bioscience team in the Early Cardiovascular, Renal, and Metabolism (CVRM) therapeutic area based in Gaithersburg, MD. You will contribute to advancing early-stage drug discovery programs by uncovering novel disease biology, validating new targets, and generating high quality experimental data that drives strategic decisions in the early pipeline.

Key Responsibilities

• Execute and interpret in vivo experiments focused on CVRM-relevant biological pathways.

• Develop, optimize, validate and implement in vivo and ex vivo models of metabolic and cardiovascular diseases to support our Early CVRM pipeline. 

• Conduct data analysis and clearly communicate results to cross-functional project teams. 

• Maintain accurate scientific documentation and ensure compliance with safety and quality guidelines.

• Stay current with scientific literature and industry advances in CVRM research.

Required Qualifications

• Bachelor’s degree in Biology, Pharmacology, Physiology, or a related field with 2+ years of relevant experience, or a Master’s degree in a related field with 0+ years of relevant experience.

• Hands-on experience with animal models, including:

• Technical expertise with handling mice and rats, including dosing via intraperitoneal (IP), intravenous (IV), subcutaneous (SC), and oral gavage routes of administration.

• Cage handling experience, including cage change, monitoring body weight and food intake.

• Expertise in blood collection methods in mice and rats, including sub-mandibular, tail-bleeds, cardiac puncture and vena cava as well as terminal tissue collections including heart, muscle, adipose, and liver.

• Strong data analysis and scientific communication skills.

• Demonstrated ability to work independently as well as collaboratively in a team setting in a fast paced R&D environment.

Preferred Qualifications

• Industry or academic research experience in early-stage drug discovery.

• Proficiency in molecular and cellular biology techniques (e.g., qPCR, Western blot, ELISAs etc.).

• Rodent surgical expertise, including subcutaneous implantation of Alzet pumps, liver biopsies, thoracic aortic constriction (TAC), etc.

• Experience working with rodent models of metabolic and cardiovascular diseases – including diet-induced obese (DIO) mice and rats, ZSF-1 rats, genetic cardiomyopathy models, AngII infusion, etc.

Key Competencies

• Strong scientific curiosity and problem-solving ability

• Rigor and attention to detail

• Clear communication and teamwork

• Ability to prioritize and manage multiple experiments

• Adaptability and learning agility

AstraZeneca offers an inspiring environment where your expertise can make a profound impact. With a commitment to continuous improvement and innovation, we embrace challenges and thrive on collaboration. Our dynamic approach ensures that every setback is an opportunity for growth. Here, you'll be part of a team that values curiosity and courage, pushing boundaries to deliver life-changing medicines to patients worldwide.

At AstraZeneca, we seize opportunities to innovate and redefine what’s possible in biopharmaceuticals. Our mission to deliver transformative medicines is underpinned by a culture of collaboration, inclusivity, and ambition. Join us in a role where your work directly gives to breakthroughs in oncology, empowering patients and changing lives.

Ready to take the next step in your career? Apply now and be part of something extraordinary!

The annual base pay (or hourly rate of compensation) for this position ranges from $92,252.00 to $138,378. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans

Date Posted

05-Mar-2026

Closing Date

18-Mar-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.