Researcher - Protein Metrology

LGC provides a range of measurement products and services which underpin the safety, health and security of the public, including reference materials and proficiency testing, genomics solutions, services and instrumentation, and expert sample analysis and interpretation. Our customers are across a number of end markets including Government, Academia Pharmaceuticals, Agricultural Biotechnology, Food, Environment.

The Protein Mass Spectrometry team delivers high quality measurement research projects to meet current and future analytical challenges as part of the LGC’s international role as the UK’s National Measurement Laboratory and Designated Institute (DI) for chemical and bio-measurement. 

The job holder will contribute to the development and validation of analytical methods to deliver NML measurement research programmes for government as well as to support private sector R&D contract commitments within the scope of protein analysis. They will be required to use advanced instrumental techniques and to employ a variety of sample preparation techniques as required.

The successful candidate will have experience in peptide and protein quantification and characterisation by mass spectrometry. Training as appropriate will be provided on traceability of measurements to the System of International Units and on the instruments required for the delivery of the projects. This is an excellent opportunity for candidates looking to progress their career in protein mass spectrometry. 

Key Responsibilities

• Provide peptide and protein quantification and characterisation capabilities through mass spectrometry to support government core metrology projects.
• Independent day-to-day planning and delivery of challenging research and development work, ensuring quality, timely delivery, and adherence to budget.
• Delivery of ad-hoc research commercial projects and comprehensive reporting of results.
• Publication and dissemination of scientific advancements and achievements.
• Build and nurture relationships with external customers and collaborators, and extend metrology networks to underpin the UK national measurement system.

Knowledge, Experience and Technical Skills

• PhD or equivalent experience in industry, academic, or clinical research.
• Demonstrated expertise in protein quantification methods via mass spectrometry, encompassing both label-free and labeled techniques (e.g. isotope dilution mass spectrometry).
• Expertise in the development and optimisation of targeted protein quantification methods, particularly MRM/SRM and PRM or equivalent experience.
• Strong understanding of protein chemistry and proteomics workflows, including sample preparation, digestion, and peptide separation techniques.
• Proficiency in mass spectrometry instrumentation and maintenance; experience with QQQ, qTOF, and HRMS (e.g. Orbitrap is a plus).
• Familiarity with bioinformatics tools and databases for protein identification and quantification.
• Strong data analysis and interpretation skills related to protein mass spectrometry.
• Excellent presentation skills, both oral and written.
• Experience in coordinating and handling long-term and short-term research projects, meeting deadlines, and preparing reports.

Person Specification

The role requires an enthusiastic scientist who will contribute to the successful delivery of analytical R&D projects. You are encouraged to share your achievements through relevant scientific publications, reports, and presentations. The following person specifications are required:

• Capability to manage both extended and brief projects independently.
• Passionate and confident scientist.
• Self-reliant and self-motivated great teammate.
• Excellent interpersonal skills.
• Strong attention to detail and a proactive attitude towards learning.
• Appreciation for working within a quality system and knowledge of good laboratory practice.

The job holder will be able to demonstrate the following behaviours in line with LGC’s values:

Passion, Curiosity, Integrity, Brilliance, Respect

About The National Measurement Laboratory

Measurement matters, as it affects everything from food and drink to medicine. 

At the NML we have a strong heritage in measurement science. We are the UK’s designated institute for chemical and bio measurement, and the home of the Government Chemist.

The Government Chemist role was created in 1909 and now it oversees the statutory function of referee analyst within the UK, resolving disputes over analytical measurements, particularly in relation to food regulatory enforcement.

The UK was one of the pioneers within the global measurement community to recognise the need to address the new and developing challenges of measurement across chemistry and biology. In 1988, the then Government Chemist launched the first UK programme to develop a chemical and bio-measurement infrastructure and the NML was born.

https://www.lgcgroup.com/uk-national-measurement-laboratory/

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Our Benefits

25 days annual leave, generous pension plan, season ticket loans, buy/sell holiday scheme, life assurance, retail discounts and more