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Research Scientist I, Molecular Biology/Biochemistry

Watchmakergenomics

Boulder, CO (Boulder, Colorado) permanent

Posted: March 10, 2026

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Quick Summary

We are seeking a Research Scientist I to support a research program focused on the development and characterization of novel, proprietary reagents. The ideal candidate will have a strong background in molecular biology and biochemistry and a PhD in a relevant field. The successful candidate will be expected to work collaboratively with a team to design, synthesize, and characterize new compounds.

Job Description

Position: Research Scientist I, Molecular Biology/Biochemistry

Position Type: Full-Time Employee

Department: Research & Development, Applications

Location: Boulder, CO (onsite)

Experience: BS+5 years; MS+3 years; PhD+0-2 years industry experience

Position Summary

Watchmaker is inviting applications for the full-time position of Research Scientist, based in Boulder, Colorado.

This position reports to a Principal Scientist, Research and Development and will be responsible for supporting a research program focused on the development and characterization of novel, proprietary reagents for a range of genomics applications. This individual will be responsible for designing, executing and documenting experimental protocols and will work closely with the broader scientific and commercial teams.

The successful candidate will thrive in a dynamic, fast-paced working environment, where ambiguity and change are common. The research scientist will contribute directly to our company culture and success. This position provides an opportunity to grow and develop as a scientist and gain valuable experience in product development and commercialization.

Responsibilities

• Plan and perform molecular biology experiments including: enzyme characterization and optimization, and next-generation sequencing sample prep

• Develop novel bioinformatics tools to analyze next-generation sequencing data

• Independently design, implement, and maintain experiments and laboratory protocols

• Carefully interpret data and accurately document the details of all experiments

• Contribute to a team responsible for launch of commercially successful enzymes and genomics products

• Participate in customer collaborations and product support

• Identify opportunities for internal process improvement

Skills and Requirements

The candidate should have a PhD (or equivalent experience) in molecular biology, biochemistry or a related discipline, with at least two years of relevant research experience. Experience in the following areas is considered highly desirable: next-generation sequencing (NGS), sample preparation, PCR, qPCR, NGS data analysis and bioinformatic pipeline development. Knowledge of DNA- and RNA-modifying enzymes is a plus.

The following skills and experience are requirements for the position:

• Demonstrated ability to execute, reproduce and troubleshoot molecular biology lab work

• Demonstrated ability to perform bioinformatic analyses

• The ability to multitask, perform consistently under pressure and work without supervision

• Strong interpersonal skills and an ability to work as an effective member of a team

• Experience with standard molecular biology techniques such as PCR, qPCR, vector design, and gene cloning methods

• Excellent organizational skills and outstanding attention to detail

• Good communication and personal task management skills and a high level of self-motivation

Education

• PhD in molecular biology, biochemistry (or related discipline), or MS with 3 years industry experience, or BS with 5 years industry experience

Compensation

The base compensation for the Research Scientist role starts at $83,000-$87,000 + bonus + equity; actual pay will be adjusted based on skills and experience. Employees are eligible for Flexible Time Off, Holidays, employer covers 75% of base medical plan with buy-up options, EAP (employee assistance program), employer paid dental, employer paid vision, employer paid $25,000 life/AD&D policy, paid parental leave, and a 401(k) retirement plan with a 4% match.

Application Requirements

To apply for the position, please submit the following in a PDF format on watchmakergenomics.com:

• Letter of motivation (upload where it says cover letter)

• Resume or Curriculum vitae, highlighting relevant qualifications and experience

Applications without a Letter of Motivation will not be considered. Local candidates preferred.

Applications will be accepted on a rolling basis and the position will remain open until filled; however, early submission is encouraged as review will begin immediately.

If selected to participate in the interview process, the names and contact information of three professional references who are able to assess your suitability for the position in terms of the specified requirements will be requested.

*** NO RECRUITMENT AGENCIES PLEASE

We are only accepting direct applications for this position. We are not working with external recruiters or agencies at this time. Unsolicited resumes or candidate submissions from third-party recruiters will not be considered and will be deemed the property of Watchmaker Genomics.

*** WE ARE AN EQUAL OPPORTUNITY/AFFIRMATIVE ACTION EMPLOYER

Watchmaker Genomics is committed to being an equal opportunity employer and creating a culturally diverse environment. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability status, age, or veteran status or any other characteristics as protected by applicable law.

All applicants will be asked if currently eligible to work in the United States of America; and if now or in the future will require visa sponsorship to continue working in the United States.

This position may be subject to pre-employment checks, including driving history check, drug screening and a background check for any convictions directly related to its duties and responsibilities. All pre-employment checks will comply with all applicable federal, state, and local laws.

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