Research Associate, Protein Sciences

ABOUT US

There are more than 9 million immunocompromised people in the United States. Almost half a million of those represent a population that are moderately to severely immunocompromised and at highest risk for severe COVID-19, including stem cell and solid organ transplant patients as well as those with hematologic cancers.

At Invivyd, Inc., we take those numbers very seriously and we come to work each day on a mission to deliver protection from serious viral infectious diseases, beginning with SARS-CoV-2. Invivyd deploys a proprietary integrated technology platform unique in the industry designed to assess, monitor, develop, and adapt to create best in class antibodies.

In March 2024, Invivyd received emergency use authorization (EUA) from the U.S. FDA for a monoclonal antibody (mAb) in its pipeline of innovative antibody candidates.

In October 2025, the FDA cleared the company's Investigational New Drug (IND) application and provided feedback to advance the company's REVOLUTION clinical program, Invivyd's development program for VYD2311, a vaccine alternative monoclonal antibody being investigated for the prevention of COVID-19.

Be part of making a difference. Be part of Invivyd.

Location: Newton, MA (on-site)

Position Summary:

In this role you will be responsible for the design and day-to-day operation antibody and protein purification, characterization and protein analytics workflows at Invivyd. This position will work collaboratively with antibody discovery researchers and project managers. As part of a small research team, you will report to a PhD scientist and have the opportunity for scientific and professional mentorship and well as ownership of your research work. You will play a key technical role in the experimentation required to discover and advance candidate antibody molecules for development. The successful candidate will serve as a key member of the R&D team, supporting the up/down selection of antibody candidates throughout the therapeutic discovery and development process.

Responsibilities:

• Contribute to Invivyd’s protein production and analytics workflow

• Demonstrates reliable technical skills in a focused number of methodological areas including various binding and biophysical characterization techniques including biosensor (Octet, Biacore) assays, thermal stability, and light scattering

• Purify proteins and antibodies using FPLC systems (Akta) and various from of chromatography

• Assist in developing new assays for protein characterization within the context of antibody discovery campaigns

• Support basic Antibody engineering efforts, including Fab and scFv preparation and purification

• Ensure effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks

• Performs initial analysis of experimental data and interprets immediate experimental outcomes and/or conclusions within established protocols

• Participates in the planning and performance of experiments within standard procedures with minimal supervision

• Troubleshoots routine technical problems within standard procedures and performs regular quality control audits on instrumentation and associated outputs

• May be expected to present during internal research and development team meetings

Requirements: Questions to consider below.

• Bachelor’s degree in molecular biology, biochemistry, or a related field, and 1+ years of bench Industry experience

• Experience in mammalian and bacterial cell culture with an emphasis on protein expression

• Strong knowledge and wet-lab experience performing protein purification and characterization using Akta FPLC systems, BLI (highly preferred), and functional assays

• Experience or understanding of various analytical methods for protein characterization and developability assessment of drug candidates is preferred

• Proactive team player and flexibility to work on multiple projects as the discovery programs evolve over time

• Ability to design and execute antibody discovery workflows and interpret in-process readouts

• Excellent verbal and written technical and non-technical communication skills

At Invivyd we strive to create a welcoming and inclusive environment. Here all applicants will receive equal consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other applicable legally protected characteristics.

Invivyd is proud to be an equal opportunity employer.

We do not accept unsolicited resumes from agencies.