Principal Scientist – LC-MS/MS Bioanalysis (PK/PD, Complex Modalities)

Confidential

Macclesfield, Cheshire permanent

Posted: April 2, 2026

Job Description

Role Overview

We are seeking a Principal Scientist to act as a subject matter expert across LC-MS/MS bioanalytical programmes supporting PK and PD studies. This role provides scientific leadership across multiple studies, focusing on complex problem-solving, assay strategy, and client engagement.

Key Responsibilities

Provide scientific leadership and SME support across LC-MS/MS studies

Lead troubleshooting of complex analytical challenges, including matrix effects, sensitivity limitations, and assay robustness

Advise on method development, optimisation, and validation strategies

Support study teams in resolving technical issues and ensuring consistent assay performance

Contribute to client interactions, including scientific discussions, data interpretation, and method justification

Support proposals, bid defences, and scientific strategy discussions

Mentor and support development of laboratory scientists

Technical Expertise

Strong knowledge of LC-MS/MS theory, including triple quadrupole and HRMS systems

Experience with sample preparation techniques such as SPE, LLE, protein precipitation, and hybrid workflows

Deep understanding of quantitative bioanalysis, including calibration strategies, selectivity, and matrix effects

Experience with Complex Modalities

Peptides and proteins

Oligonucleotides

Antibody-drug conjugates and related conjugates

Regulatory and Client Experience

Extensive experience working under GLP and GCP

Strong understanding of regulatory guidance (FDA, EMA, MHRA, M10)

Experience supporting audits and regulatory inspections

Proven ability to lead scientific discussions with clients and defend analytical approaches and data

Ability to communicate complex technical issues clearly and challenge client assumptions where appropriate

Qualifications and Experience

PhD in Analytical Chemistry or related field, or MSc with significant industry experience

10 to 15 or more years of LC-MS/MS bioanalysis experience

Demonstrated expertise in method development, validation, and advanced troubleshooting

Why Apply Through MisuJob?

AI-Powered Job Matching: MisuJob uses advanced artificial intelligence to analyze your skills, experience, and career goals. Our matching algorithm compares your profile against thousands of job requirements to find positions where you have the highest chance of success. This saves you hours of manual job searching and ensures you only see relevant opportunities.

One-Click Applications: Once you create your profile, applying to jobs is effortless. Your resume and cover letter are automatically tailored to highlight the most relevant experience for each position. You can apply to multiple jobs in minutes, not hours.

Career Intelligence: Beyond job matching, MisuJob provides valuable career insights. See how your skills compare to market demands, identify skill gaps to address, and understand salary benchmarks for your experience level. Make data-driven decisions about your career path.

Frequently Asked Questions

How do I apply for this position?

Click the "Register to Apply" button above to create a free MisuJob account. Once registered, you can apply with one click and track your application status in your dashboard.

Is MisuJob free for job seekers?

Yes, MisuJob is completely free for job seekers. Create your profile, get matched with jobs, and apply without any cost. We help you find your dream job without any hidden fees.

How does AI matching work?

Our AI analyzes your resume, skills, and experience to understand your professional profile. It then compares this against job requirements using natural language processing to calculate a match percentage. Higher matches mean better fit for the role.

Can I apply to jobs in other countries?

Absolutely. MisuJob features jobs from companies worldwide, including remote positions. Filter by location or look for remote opportunities to find jobs that match your preferences.

Ready to Apply?

Join thousands of job seekers using MisuJob's AI to find and apply to their dream jobs automatically.