Principal Investigator, Gastroenterology
Confidential
Posted: January 30, 2026
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Quick Summary
We are seeking a Principal Investigator to lead a team of researchers in the field of gastroenterology, working closely with our clinical sites in Southern California.
Required Skills
Job Description
About Kinetic Clinical Research
Kinetic Clinical Research (“KCR”) is a fast-growing, multi-site clinical research organization built by physicians and operators who understand the realities of modern clinical practice. Following the consolidation of several successful Southern California research sites, KCR is expanding its gastroenterology research portfolio and is seeking an entry level or an experienced Gastroenterologist to serve as a Principal Investigator (PI) and long-term clinical partner.
The Opportunity
This role is ideal for a gastroenterologist who wants to:
Expand or transition into clinical research leadership
Work in a supportive, well-staffed research environment
Participate in a growing research platform with long-term upside
Potentially progress toward profit-sharing or equity participation based on contribution, performance, and mutual alignment
Role Overview
As a Principal Investigator, you will lead and oversee GI related clinical trials, working closely with KCR’s experienced operations, regulatory, and recruitment teams. You focus on medicine and oversight — we handle the infrastructure.
Key Responsibilities
Serve as Principal Investigator on gastroenterology clinical trials (e.g., IBD, NASH/MASH, IBS, GERD, motility, liver disease, or related indications)
Provide medical oversight and ensure subject safety and protocol compliance
Review and approve study protocols, informed consent documents, and safety reports
Supervise Sub-Investigators and collaborate with CRCs and site staff
Participate in Sponsor meetings, feasibility assessments, and monitoring visits
Support patient recruitment and retention through clinical engagement
Maintain compliance with FDA regulations, ICH-GCP, IRB requirements, and KCR SOPs
What We Offer
Turnkey research infrastructure (experienced CRCs, regulatory, recruitment, pharmacy, and QA support)
Access to active and upcoming GI studies with strong Sponsor relationships
Flexible scheduling (part-time or per-diem arrangements available)
Competitive per-study or hourly compensation
Administrative and operational support so you can focus on clinical work
A collegial, transparent leadership team that values physician input
Growth & Partnership Potential
KCR is building for the long term. For physicians who demonstrate strong leadership, study performance, and alignment with our mission, there is a clear pathway to expanded roles, including:
Lead Investigator status across multiple studies
Involvement in study selection and portfolio development
Profit-sharing opportunities tied to site growth and performance
(This is not a promise or guarantee, but a genuine opportunity we actively pursue with the right partners.)
Qualifications
MD or DO with Board Certification or Eligibility in Gastroenterology
Active, unrestricted California medical license
Prior Principal Investigator or Sub-Investigator experience preferred (but not required)
GCP-trained or willing to complete GCP training
Interest in clinical research, innovation, and collaborative growth
Why Physicians Choose KCR
We respect your time and expertise
We invest in systems and staff — not shortcuts
We view investigators as partners, not vendors
We are building something scalable, reputable, and physician-led