Pioneering Medicines: Scientist / Senior Scientist, Invitro Pharmacology Contractor

Position Summary:

We are seeking an on-site, lab-based in-vitro scientist in drug discovery who enjoys collaborating with cross-functional teams. Under appropriate guidance, the role involves designing research studies, performing experiments, and analyzing data. The
ideal candidate will preferably have expertise in cardiovascular physiology including but not limited to cardio-metabolic or cardiac physiology, along with experience in in-vitro biochemical assays, cell culture, organoid models, hiPSC cultures, cell biology assays, and ex vivo techniques. As and when required, this person will work closely with other stakeholders to help achieve the research goals.

Key Responsibilities:

• Support in vitro screening, characterization, and mechanism of action studies by utilizing various biochemical, biophysical, and cellular techniques to explore signaling pathways for target identification and validation, employing modalities like small molecules, peptides, and other biologics.

• Develop cell-based assays utilizing primary cardiomyocytes, cardiac cell lines, iPSCs, and organoids, along with ex vivo experiments to aid in in vitro pharmacology and translational research.

• Collaborate with key stakeholders of the in vitro, in vivo, and translational teams and other necessary stakeholders to support daily laboratory operations.

• Participate and present data at internal and external meetings

Basic Requirements:

• Ph.D. in biochemistry, biotechnology, biophysics, biology, or a related field.

• 3+ years of post-doctoral experience is preferred

• Over three years of experience in academia and/or industry, ideally in the cardiometabolic therapeutic field, is a plus.

• Broad experience in protein and peptide chemistry is preferable

• Have working Skilled in culturing and handling human primary cells, including primary cardiomyocytes and hiPSC-derived cardiomyocytes, is preferable

• Expertise working on molecular biology methods, DNA, RNA isolation, siRNA, and transduction in primary cells.

• Proficiency in common laboratory techniques such as qPCR, flow cytometry, ELISA, Western blotting, plate reader assays, and microscopy.

• Working knowledge of invitro pharmacology, in cell-based systems.

• Attention to detail and ability to analyze and summarize scientific data, clearly communicate updates and reports to the team and stakeholders, and perform detailed documentation of experimental results via ELN (Electronic Lab Notebook))

• Excellent verbal communication, presentation, and interpersonal skills are required.

• Proficient in scientific software (e.g., GraphPad Prism, FlowJo, etc.)

• Publication record in cardiovascular, cardiometabolic, or related research.

Additional Qualifications:

• Industrial experience or experience working with academic/industrial collaborators and/or CROs preferred

• Research background in cardiology or metabolism.

• Hands-on experience with gene-based approaches such as CRISPR and RNA interference is a plus

• Understanding of the general drug discovery & development process, from target identification and validation is a bonus.

Job Complexity

• Moderate to high complexity.

LOCATION: Cambridge, MA

ABOUT FLAGSHIP PIONEERING

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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The salary range for this role is $108,000 - $175,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.