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Medicinal Chemistry Intern

Hexagonbio

Menlo Park, CA permanent

Posted: March 13, 2026

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Quick Summary

A 3-month internship in Medicinal Chemistry focusing on developing next-generation ADCs with natural product evolution using genomics and machine learning.

Job Description

About Hexagon Bio:

Hexagon Bio leverages a genomics-based platform and understanding of natural product evolution to develop next-generation antibody drug conjugates (ADCs) with novel payloads for cancer. We use data science, genomics, machine learning, synthetic biology, and automation to discover potent, evolutionarily refined small molecules from microbial genomes, and apply medicinal chemistry to optimize these molecules into truly transformative medicines.

Job description:

Hexagon Bio is looking for a motivated Medicinal Chemistry Intern to join our team for 3-5 months. As a chemistry intern, you’ll have the opportunity to carry out complex, multistep chemical syntheses while contributing to cutting edge antibody-drug conjugate discovery programs. You will gain valuable exposure to medicinal chemistry strategies as well as drug discovery more broadly. This role offers a unique opportunity to grow your career through hands-on laboratory work and cross-functional interaction with various scientific disciplines, including analytical chemistry and biology.

This is an onsite, full-time, temporary (3-5 months) lab-based internship in Menlo Park, California.

Key Responsibilities:

During this internship, you will be mentored by senior scientists while taking on the following tasks:

• Synthesis & Characterization: Perform multistep synthesis, purification, and characterization of new bioactive molecules.

• Design Support: Assist in the structure-based and hypothesis-driven design of new drug compounds.

• Research Communication: Effectively summarize and communicate your research findings to the broader team.

• Lab Safety: Execute complex laboratory procedures quickly, efficiently, and safely.

Requirements:

• Education: progress toward or completion of Bachelor’s degree (BS) in Chemistry or related field.

• Experience: Proven experience working independently in an organic chemistry laboratory. Hands-on experience outside of a teaching laboratory is a must.

• Technical Skills: Familiarity with multistep organic synthesis and standard purification/characterization techniques.

• Availability: Ability to work full-time onsite at our Menlo Park, CA laboratories for the duration of the internship.

• Communication: Ability to summarize and present scientific data.

What We Offer:

• A flexible and dynamic work environment where you pave your own path, Hexagon cultivates employees' unique strengths at all levels and provides mobility across departments.

• “All Hands Meetings” provide an opportunity to share company and team updates. These meetings are rooted in our value of transparency. They are designed to foster a culture of collaboration, curiosity, and open communication.

• Access to scientific conferences throughout the year.

• A range of amenities, courtesy of the Menlo Park Labs business park, including shuttle, gym, rock-climbing wall, pool, sauna, sports courts, cafe, bike lockers, and free EV charging stations.

• Opportunities to engage with the Hexagon community through team-building events like our Hexagon Happy Hours and holiday parties.

Additional Information:

The salary range for this position is $25 - $35 per hour. Our salary ranges are determined by role, level, and location. The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across California locations. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training.

Hexagon Bio is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, disability status, membership in an organization, or any other non-merit factors

Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.

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