Manager, GMP Supply Planning & Procurement

Who We Are

Arcellx is a public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible.

Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California. At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work.

What Matters to Us

Living our core values is essential to maintaining a work environment that is high-performing, inclusive, and collaborative. We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team.

Arcellx Core Values

• Start with authenticity: We foster an inclusive environment where each person can bring their authentic self to work.

• Think ‘we’ before ‘me’: We prioritize collective success, collaborating and supporting one another to achieve our shared goals.

• Embrace the challenge: We deliver exceptional results by working with shared determination and a commitment to doing what’s right.

The “Fine Print” – What You’ll Do

In this role, you’ll ensure uninterrupted, compliant, and efficient supply of GMP raw materials, consumables, and services to support Arcellx’s manufacturing operations. This role combines strategic planning, supplier risk management, and tactical execution, with ownership for Arcellx manufacturing supply operations and broader supply chain activities.

• GMP Material Planning & Availability Management

• Execute material requirements planning (MRP) for GMP manufacturing, gowning, and operational needs.

• Establish and maintain safety stock levels, reorder points, and reorder quantities.

• Translate forecast changes and production schedules into actionable material plans.

• Develop scenario-based planning to address variability in production schedules, patient demand and supplier lead times.

• Procurement Operations & Process Ownership

• Develop, maintain, and continuously improve compliant SOPs, work instructions, and process controls for P2P and S2D.

• Ensure workflows, master data, integrations, and reporting are audit-ready and aligned with regulatory expectations.

• Purchase Order Execution & System Management

• Execute the end-to-end purchase order lifecycle in the ERP and ClearSpider systems.

• Manage PO creation, review, issuance, tracking, changes, transfers, returns, and replacements.

• Ensure accuracy, timeliness, and compliance with GMP and operational requirements.

• Supplier Management & Performance Oversight

• Support the maintenance of strong, compliant supplier relationships.

• Support and where applicable, drive supplier issue resolution, complaint management, and follow-up activities.

• Track, trend, and report supplier performance metrics, including OTIF, lead-time adherence, and service reliability.

• Supplier Change, Alternate & Substitute Strategy Execution

• Monitor and support supplier-driven material changes, including notifications, impact assessments, qualification support, and discontinuations.

• Define and execute alternate and substitute material strategies to mitigate supply risk.

• Coordinate implementation and lifecycle management of alternate/substitute materials with Quality, Manufacturing, and Technical Operations.

• Strategic Sourcing, Contracts & Supply Continuity

• Manage GMP raw material supplier contracts, including pricing, lead times, service levels, and commercial terms.

• Support sourcing, negotiation, and contract execution across the organization.

• Lead second-sourcing and supply continuity initiatives to reduce single-source dependency and improve resilience.

• Risk Management, Escalation & Audit Readiness

• Identify critical material risks, including long-lead, single-source, and capacity-constrained items.

• Develop mitigation plans and escalate risks to supply chain leadership.

• Ensure procurement, supplier, and material planning records are complete, accurate, and inspection-ready for internal and external audits.

• Cross-Functional Collaboration & Continuous Improvement

• Partner with Manufacturing, Quality, Finance, and Technical Operations to align procurement and material planning with operational priorities.

• Drive continuous improvement initiatives focused on cost optimization, service performance, compliance, and data integrity.

• Analyze supplier performance and material spend data to inform sourcing strategies and operational improvements.

Skills and Experience We Look For

• 6+ years of experience in pharmaceutical/biotechnology purchasing and/or sourcing.

• Proven experience managing GMP suppliers.

• Hands-on experience with ERP systems and in developing reports

• Strong understanding of GMP requirements related to raw materials, supplier management, and change control.

• Must be able to work independently in a startup environment

• Exceptional communication and interpersonal skills.

• Ability to work in a fast-paced environment.

• Ability to work in a lab setting/environment and able to handle materials up to 50lbs.

Rewards at Arcellx

Our people are our greatest asset, and supporting their well-being is an essential part of delivering on our mission and impacting the lives of patients. Putting this belief into practice means offering strong compensation and benefits.

The base salary range for this position is $115,000 - $155,000 per year. Where a candidate falls within that range is determined by factors such as years of experience. Our compensation package also includes an annual bonus based on company goals and an equity (RSU) grant. We do offer relocation assistance for roles if required.

Our market-leading benefits package includes: 100% coverage for medical, dental and vision for team members and dependents, unlimited vacation, a 3-day weekend every month, fully-paid parental leave for up to 6 months, tuition reimbursement, 401k employer contribution and more.

Join us in our quest to reimagine cell therapy and destroy cancer. For more on our technology, culture, and team, go to www.arcellx.com.

#LI-Onsite