Lead Product Manager, Clinical Genomics

Lead Product Manager, Clinical Genomics Engineering

Natera offers genetic risk assessment and diagnostic tests to patients through medical providers. The Clinical Genomics Engineering organization builds software that supports complex, regulated workflows spanning tertiary analysis workflows including variant interpretation, clinical review, and reporting. As Natera scales across Women’s Health, Oncology, and Organ Health, delivering cohesive, reliable, and compliant software experiences is foundational to clinical quality and commercial success.

Natera is seeking a Lead Product Manager to define and drive strategy for core components of the Results, Interpretation, and Reporting (RIR) platform. This role is responsible for shaping scalable, compliant, and cohesive clinical software systems that support complex genomics workflows across multiple business units. The Lead PM will operate as a platform-level owner, ensuring long-term architectural soundness, regulatory robustness, and measurable clinical and operational outcomes.

Initial Focus and Scope Evolution

The Lead Product Manager will lead cross-functional alignment across engineering, clinical, quality, and downstream systems to ensure RIR components operate as a cohesive, scalable platform. This role will identify systemic gaps, resolve cross-team tradeoffs, and drive architectural and workflow decisions that support long-term growth and regulatory compliance.

This role will initially own one or more RIR software components or initiatives, with responsibility for defining long-term strategy, aligning cross-component workflows, and ensuring scalable architecture across user-facing applications, data contracts, and backend services. The Lead PM will drive strategic investment decisions, establish standards for usability and reliability, and ensure systems meet evolving clinical, operational, and regulatory requirements.

As business needs evolve, this role will expand to influence and coordinate across multiple RIR components, driving cohesive workflow design, shared data standards, and platform-level scalability across Women’s Health, Oncology, and Organ Health.

Primary Responsibilities

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Define and drive multi-year product strategy and roadmap across one or more RIR components, ensuring alignment to clinical quality, regulatory requirements, and commercial scale objectives

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Influence platform-level technical direction in partnership with engineering leadership

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Partner closely with software engineering, bioinformatics, clinical domain experts, quality, regulatory, and other product teams

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Translate business, clinical, and operational needs into clear, actionable product requirements

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Define and evolve end-to-end user workflows, including UI/UX requirements and supporting backend functionality

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Drive cross-team alignment on shared data contracts and workflow standards

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Mentor and raise the bar for product management within the RIR organization

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Own measurable improvements in clinical workflow efficiency, reliability, and operational scalability

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Establish prioritization frameworks that balance regulatory risk, clinical impact, technical scalability, and business outcomes across RIR investments.

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Develop and track quantitative metrics related to usability, performance, reliability, and adoption

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Lead delivery teams with clear strategic direction, ensuring requirements reflect long-term platform goals, validation readiness, and system interoperability.

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Proactively identify systemic risks, architectural constraints, and workflow inefficiencies that may limit scale or regulatory robustness, and lead cross-functional initiatives to resolve them

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Partner with Quality and Regulatory leadership to shape validation strategy, risk classification, traceability, and audit readiness for RIR software systems.

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Create clear, data-driven written proposals and presentations to support stakeholder alignment and decision-making

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Act as a subject matter expert for owned components, supporting design, testing, validation, rollout, and ongoing use

Qualifications

Required

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Bachelor’s degree in life sciences, engineering, computer science, statistics, or equivalent experience

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7+ years of experience in software product management, including ownership of complex, multi-team or platform-level initiatives

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5+ years experience working on production software in healthcare, clinical genomics, or other regulated lifesciences domains, with demonstrated impact on validation, compliance, and system scalability

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Demonstrated experience influencing engineering architecture and long-term technical investment decisions

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Proven ability to drive alignment across highly matrixed organizations without direct authority
Track record of independently operating in ambiguous environments and establishing product direction

Preferred

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Experience with clinical genomics and variant processing and interpretation workflows

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Experience owning user-facing applications, tools, or operational software

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Familiarity working with backend services, APIs, or data-driven systems

Knowledge, Skills, and Abilities

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Ability to operate effectively at both tactical and strategic levels, connecting detailed execution to broader platform vision.

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Strong analytical skills with attention to quality, reliability, and user outcomes

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Leads technical design discussions and critically evaluates architectural tradeoffs to ensure scalability, reliability, and regulatory integrity

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Proven ability to influence without authority and drive alignment across teams

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Clear, concise written and verbal communication skills across technical and non-technical audiences

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Ability to manage multiple initiatives in a fast-paced, regulated environment

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Familiarity with Next Generation Sequencing concepts is beneficial

Compensation & Total Rewards

This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.

This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including:

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Annual performance incentive bonus

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Long-term equity awards

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Comprehensive health benefits (medical, dental, vision)

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401(k) with company match

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Generous paid time off and company holidays

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Additional wellness and work-life benefits

Compensation Range
$141,300—$194,250 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com.

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents.

Link: https://www.natera.com/notice-of-data-collection-california-residents/

Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

For more information:
- BBB announcement on job scams
- FBI Cyber Crime resource page