Executive Director, Medical Affairs (Dissemination & Evidence Generation)

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

The Executive Director, Dissemination & Evidence Generation at Arrowhead Pharmaceuticals is a senior Medical Affairs leader responsible for setting and executing the cardiometabolic strategy for scientific dissemination and medical value evidence across the portfolio. This individual leads the Publications team and the Medical Value Evidence & Outcomes (MVEO) team and ensures that evidence generation and communication strategies are integrated, strategic, and aligned with corporate objectives.

This role requires a strong, enterprise-minded leader who can unify scientific dissemination and value evidence under a cohesive strategy, elevate standards of execution, and serve as a respected partner. The Executive Director will be a core member of the Medical Affairs Leadership Team and help shape the broader function’s vision, priorities, and culture, reporting to the VP of Medical Affairs.

This is a full-time, onsite position at Arrowhead’s Corporate Headquarters in Pasadena, CA.

Responsibilities

Medical Affairs Scientific Dissemination

• Develop and lead the overarching strategy for scientific dissemination and medical value evidence across all assets.

• Ensure alignment between evidence generation plans, publication strategy, and value demonstration priorities.

• Partner with Medical Affairs asset leads to integrate dissemination and evidence plans into overall product strategies.

• Anticipate evolving external evidence expectations (clinical, payer, guideline, and policy) and adapt strategy accordingly.

• Establish clear governance, prioritization frameworks, and performance metrics across teams.

• Ensure high-quality, timely, and scientifically rigorous dissemination of clinical and real-world data.

• Promote a culture of scientific rigor, accountability, and cross-functional partnership

Medical Value Evidence & Outcomes Leadership

• Oversee the MVEO strategy, including health economics, real-world evidence, outcomes research, and value demonstration initiatives.

• Ensure evidence generation plans support payer engagement, reimbursement discussions, and policy positioning.

• Partner closely with Market Access to align value evidence with access strategy.

• Guide development of economic models, RWE studies, and outcomes data that strengthen product differentiation

Requirements

• Doctorate degree in life sciences, healthcare, or related field required

• 15+ years experience in Medical Affairs or related functions within the pharmaceutical or biotech industry with a strong understanding of Medical Affairs and compliance requirements.

• Significant experience leading publications and/or health economics and outcomes research.

• Proven success building and leading high-performing medical teams.

• Experience supporting both pipeline and commercial-stage assets.

• Strong understanding of payer evidence requirements and value communication.

• Excellent organizational, project management, and communication skills.

• Ability to work effectively across functions and with external stakeholders in a fast-paced environment.

• Demonstrated ability to manage multiple projects simultaneously with strong attention to detail.

Preferred

• Advanced training in lipidology, cardiometabolic disease, or rare/metabolic disorders

California pay range
$280,000—$320,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.

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