Director / Senior Director, Human Resources - Commercial

“Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit https://mineralystx.com. Follow Mineralys on LinkedIn, Twitter and Bluesky”

Mineralys is a fully remote company.

The Director / Sr Director, Human Resources – Commercial will serve as the primary HR Partner to Mineralys’ Commercial organization as the company prepares for its first commercial launch. This role will act as a trusted advisor to business leaders, aligning people strategies with commercial objectives while fostering a high-performance, compliant, and values-driven culture in a rapidly scaling, highly regulated environment.

Key Responsibilities

Strategic Business Partnership

• Serve as a strategic HR partner to Commercial and Field leadership across Sales, Marketing, Market Access, Training and Commercial Operations

• Translate commercial objectives into integrated people strategies that support rapid growth, capability building, and organizational effectiveness

• Provide data-driven insights and recommendations on workforce planning, organizational design, job architecture, compensation planning and talent needs as the Commercial organization scales

Talent Management & Development

• Partner with leaders on talent assessment, succession planning, and leadership development initiatives

• Supports annual objective setting and mid-year and year-end performance assessment processes

• Participates in the design and execution of field incentive compensation programs

• Supports all performance management processes, including coaching, feedback, and development planning

• Identify capability gaps within the Commercial organization to deliver targeted development solutions

Employee Relations & Engagement

• Act as a first point of contact for employee relations matters, ensuring fair, consistent, and timely resolution in compliance with company policies and employment laws

• Coach managers on effective people leadership, engagement, and change management during periods of growth and transformation

• Support employee engagement initiatives that reinforce Mineralys’ values of Collaboration, Integrity, Quality, Trust, and Urgency

Change Management & Organizational Effectiveness

• Lead and support change management efforts related to commercial build-out, launch readiness, and evolving operating models

• Support commercial teams to ensure alignment and consistency across a geographically dispersed workforce

Compliance & Governance

• Ensure adherence to all employment laws, regulatory requirements, and internal policies, particularly in a pharmaceutical commercial environment

• Partner with Legal and Compliance to mitigate risk and support sound, compliant people decisions

Qualifications

Required

• BS/BA degree in Human Resources, Business Administration, or a related field

• 7+ years of progressive HR experience, with demonstrated success as an HR Business Partner

• Experience supporting Commercial organizations, preferably within pharmaceutical, biotech, or life sciences companies

• Strong knowledge of U.S. employment law and HR best practices

• Proven ability to influence and partner effectively with senior leaders

• Excellent communication, coaching, and problem-solving skills

Preferred

• Master’s degree or HR certification (e.g., SHRM-CP/-SCP, PHR/SPHR)

• Experience supporting field-based sales organizations, including periods of rapid growth or launch

• Familiarity with specialty pharma, rare disease, or launch-stage commercial models

• Experience working in a matrixed, fast-paced, early-stage environment

Travel

• This position requires up to 10% travel. Frequently travel is outside the local area and overnight.

US Salary Range: $200,000 - $250,000

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