Director, Medical Affairs (Cardiometabolic)

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

The Director, Medical Affairs at Arrowhead Pharmaceuticals serves as the strategic and scientific lead for the cardiometabolic portfolio and is responsible for developing and executing Medical Affairs strategies for pipeline assets. This individual ensures the delivery of accurate, compliant, and scientifically rigorous medical guidance to both internal and external stakeholders. A core responsibility of this role is to serve as a key cross-functional partner to the Commercial organization, providing medical insight that informs strategy while upholding scientific integrity.

Reporting to the Executive Director, Medical Affairs Strategy, this role plays a central part in shaping the scientific narrative, supporting launch readiness, and translating complex clinical data into meaningful insights that inform commercial strategy while preserving medical integrity.

This is a full-time, onsite position at Arrowhead’s Corporate Headquarters in Pasadena, CA.

Responsibilities

• Medical Affairs Strategy for pipeline

• In partnership with Medical Affairs Strategy Executive Director, develop and execute the comprehensive Medical Affairs strategy for pipeline molecules across the product lifecycle.

• Translate clinical data, regulatory milestones, and competitive insights into a clear medical strategic plan.

• Partner with Medical Communications on the development of scientific platforms, core data decks, and medical communication materials.

• Identify evidence gaps and contribute to evidence generation planning in collaboration with Clinical Development and MVEO.

• Contribute to the development of medical education initiatives related to zodasiran.

• Support scientific exchange with external experts, as appropriate.

• Assist in preparing medical content for advisory boards, speaker training, and scientific meetings.

• Cross-Functional Collaboration

• Serve as the Medical Affairs partner with the Commercial Team.

• Answer complex medical questions from Commercial, Market Access, and other internal stakeholders.

• Help translate clinical and scientific data into insights that enhance field effectiveness while maintaining scientific integrity.

• Participate in brand planning and launch readiness activities from a medical perspective.

• Provide accurate, timely, and compliant medical guidance to inform promotional strategy and materials.

• Review promotional materials for scientific accuracy and medical appropriateness.

Requirements

• Doctorate degree (PharmD or PhD) in life sciences, healthcare, or related field required

• 5+ years experience in Medical Affairs or related functions within the pharmaceutical or biotech industry with a strong understanding of Medical Affairs activities and strategy and compliance requirements.

• Experience developing collaborative cross-functional relationships

• Excellent organizational, project management, and communication skills.

• Demonstrated ability to manage multiple projects simultaneously with strong attention to detail.

Preferred

• MD

• Advanced training in lipidology, cardiometabolic disease, or rare/metabolic disorders

California pay range
$230,000—$260,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.

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