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Director, Human Resources Business Partner

Tangotherapeutics

Boston, MA (201 Brookline Avenue, Suite 901, Boston, MA) permanent

Posted: December 18, 2025

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Job Description

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts

Summary

Reporting to the CHRO, the Director, Human Resources Business Partner (HRBP) provides HR leadership and consultation to client groups within one or multiple functions, including Clinical Development, Regulatory, and other key late-stage clinical areas. The HRBP is a trusted advisor to leaders, providing expert HR advice and advanced solutions that enable the achievement of business strategies by leveraging a significant understanding of the operating environment. This role drives talent management and helps architect and manage organizational change. The role is responsible for the delivery of HR programs and services such as talent/career development, manager coaching and consultation, employee relations, and performance management.

Your role

• Provides strategic HR leadership and expert guidance to assigned client groups, along with consultation and delivery of HR programs and services to achieve key business objectives

• Leverages previous experience and data to provide critical insights into business and talent trends that inform the overall business and HR priorities. Provides insights in a simple, creative, and relevant way that challenges current thinking, informs business decisions, and shows how decisions impact business outcomes

• Proactively defines, builds, and implements value-added HR strategies and solutions

• Advises functional leaders in solving complex issues related to organization design, development, and change leadership

• Establishes strategies and tactics to enable the business to attract, develop, and retain high-quality talent at all levels to support the growth objectives, opportunities, and strategies of the business

• Leads the strategic workforce planning efforts to ensure the people and talent strategy is in alignment with the organization's long range strategic plan (identification of long-term capability needs, talent acquisition and succession planning)

• Builds strong partnerships within the HR team to enhance the function’s effectiveness in providing solutions to key business needs and to roll out corporate-wide programs that enhance the overall employee experience and support growth and success of overall business strategy

• Works with clients to implement and manage key HR processes, such as year-end performance management (performance assessment, calibration, and compensation planning)

• Partners with Talent Acquisition (TA) to ensure TA strategy is in place to deliver on key hires and growth plans

What you bring

Education and Experience:

• Undergraduate degree in human resources or related, relevant discipline

• Typically requires 10 years of experience or the equivalent combination of education and experience

Knowledge and Skills:

• Experience developing and implementing HR strategies

• Track record of developing strategic workforce plans, from conception to implementation

• Highly experienced in talent management, succession planning, and career growth and development

• Strong experience managing and/or leading culture and change management or organizational effectiveness initiatives

• Experience and expert understanding of management development, employee relations, data and analytics

Traits and Qualities:

• Ability to influence positively including in situations without direct authority

• Ability to work independently and collaboratively, in a matrix team environment consisting of internal and external team members

• Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines

• Excellent planning, organization and time management skills including the ability to support, prioritize, and multi-task

• Highly collaborative team player who fosters open communication and develops important relationships with key stakeholders

• Outstanding interpersonal and communication abilities with a high degree of emotional intelligence

• Possess the ability, business maturity and interpersonal savvy to be proactive and establish credibility with all employees across the Company

• Have proven communication skills, both written and verbal, and the ability to present information clearly to a variety of audiences

• Able to learn quickly and take a project from idea to execution (strategy to operational) quickly and independently

• Thrives in high energy and fast paced organization with ongoing simultaneous initiatives

• Builds consensus and alignment and persuades others to take action

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Salary range
$163,200—$244,800 USD

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