Director, ECS – SAP Manufacturing

Introduction to role

Are you ready to leverage technology to make a real impact on patients’ lives? Do you want to apply your IT expertise to help a company turn science into life‑changing medicines? Join us as a Director, ECS – SAP Manufacturing at our Global Innovation and Technology Centre in Guadalajara, Mexico. You will support a multi‑year ERP transformation to S/4HANA while maintaining our existing SAP estate and portfolio of work. We ensure that changes are aligned to target architecture, high in design quality, timely, affordable, sustainable, and introduced with minimal risk to operations.

Accountabilities

As Director, ECS – SAP Manufacturing, you will bridge SAP architects/senior consultants and manufacturing operations, translating plant needs into fit‑to‑standard SAP Manufacturing solutions with minimal customization. You will champion clean core and global template standards for agile shop‑floor and planning enhancements across regions, aligned with AstraZeneca QMS and pharmaceutical regulations.

• Fit‑to‑standard design: Lead designs for discrete and process manufacturing across ECC (PP, PP‑PI, QM, PM) and S/4HANA (embedded PP/DS, DDMRP, Fiori).

• Embed compliance by design: Integrate GMP/GxP, data integrity (ALCOA+), Annex 11/Part 11, QA/CSV validation, and controlled change management into process and solution design.

• Master data and change control: Govern standards for materials, BOMs/recipes, routings/phases, work centers/resources, and inspection characteristics, plus engineering change management.

• Shop‑floor integrations: Orchestrate standard‑first integrations among S/4, DMC/MII, EWM, LIMS/PLM/IoT equipment; ensure validated interfaces and event‑driven data capture for batch records and release.

• Planning and scheduling: Optimize with PP/DS and DDMRP; minimize custom heuristics; plan changes with rehearsal and risk‑based validation.

• Incident triage and resolution: Resolve MRP performance, PP/DS constraints, confirmations, batch/serial inconsistencies, QM holds, and PM breakdown impacts while protecting the validated state and clean core.

• Analytics and controls: Deliver SAC manufacturing KPIs (OEE, yield, scrap, schedule adherence) and ESG‑SFM metrics; automate controls via ICSM/IAG for audit readiness.

Essential skills/experience

• Education: Bachelor’s degree in computer science, information systems, engineering, or equivalent experience.

• Pharma manufacturing: Experience in GMP/GxP environments, batch records, quality processes, and validated system changes aligned to an AstraZeneca‑like QMS.

• SAP ECC core: Hands‑on with PP or PP‑PI, QM, PM; strong understanding of master data and shop‑floor execution.

• S/4HANA manufacturing: Working knowledge of embedded PP/DS, DDMRP, and Fiori; ability to apply standard‑first, clean‑core designs.

• Regulatory knowledge: Practical understanding of ALCOA+, Annex 11/Part 11 for electronic records and signatures, and QA/CSV deliverables.

• Integration: Experience with CPI/PI‑PO, IDoc, OData/REST; exposure to DMC/MII for shop‑floor data capture and EWM/WMS for material movements; basics of LIMS/PLM integration.

• Agile delivery and validation: Delivery in validated plant environments, coordinating rehearsals, cutovers, and hypercare with transport discipline and traceable evidence.

• Human skills: Excellent English communication (written and verbal), negotiation and influencing, engagement with senior stakeholders in operations, quality, and engineering, crisis/escalation management, and proven mentoring/coaching.

Desirable (trainable) skills

• PP/DS deepening: Constraint‑based scheduling, pegging strategies, performance tuning, and exception handling.

• DMC: Electronic batch record data capture, e‑signatures, role‑based Fiori apps for operators.

• QM advanced: Sampling strategies, stability studies, COA automation, integration to deviations/CAPA workflows.

• PM advanced: Reliability‑centered maintenance, calibration processes, integration of IoT telemetry.

• BRH: Manufacturing policy enforcement (recipe approvals, batch release rules) without custom code.

• SAC: KPI design for OEE, yield/scrap analytics, deviations tracking; data modeling and storytelling.

• BTP: Side‑by‑side extensibility and lightweight shop‑floor apps; RAP/Fiori/UI5 familiarity.

• ESG‑SFM: Sustainable manufacturing metrics and reporting alignment.

• ICSM/IAG: Automated control design and SoD models for shop‑floor, quality, and maintenance roles.

• ATTP linkage: Awareness of how serialization impacts manufacturing and packaging workflows.

Success measures

• Fit‑to‑standard adoption: Minimal WRICEF and strong validation evidence.

• Stable plant operations: Smooth deployments with improved planning, execution, and quality metrics.

• Audit strength: Robust outcomes with consistent batch records and sustainability reporting via SAC and ESG solutions.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life‑changing medicines. In‑person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Ready to take on this challenge and help redefine digital manufacturing? Apply now.

Date Posted

19-feb-2026

Closing Date

12-mar-2026

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.