CRO Leader, DAC Platform Specialist (Shanghai)

Position Overview

Orum Therapeutics is pioneering the next generation of precision medicine by marrying the power of Targeted Protein Degradation (TPD) with the specificity of Antibodies. As our first scientific operations hire in China, you will oversee the external development of our Degrader-Antibody Conjugate (DAC) pipeline, including our lead GSPT1-directed programs and novel payload discovery efforts. You will be the technical and cultural bridge between our Lexington/Daejeon hubs and our Chinese CRO partners.

Scientific Vendor Oversight: Manage high-stakes projects at CROs (e.g., WuXi Biologics/AppTec), specifically overseeing the synthesis of proprietary molecular glue degrader payloads and their conjugation to therapeutic antibodies.

Vendor Scouting & Selection: Proactively identify and vet CROs that offer specialized expertise in relevant in-vitro activity assays, in vivo studies (efficacy and toxicology), linker-payload synthesis, and complex bioconjugation.

Platform Innovation: Support the expansion of our TPD²® (Degradation) and TPS²™ (Stabilization) platforms by identifying specialized Chinese partners capable of advanced physics-based modeling and machine learning-driven payload design.

Pipeline Advancement: Drive IND-enabling studies for candidates like ORM-1153 (CD123-targeting DAC) and support ongoing clinical-stage programs.

Strategic Sourcing: Navigate the "China price" ecosystem to find cost-effective, high-quality alternatives for R&D without compromising the integrity of our AnDC™ (Antibody neoDegrader Conjugate) technology.

Timeline Efficiency: Drive operational efficiencies to reduce discovery timelines by leveraging parallelized local workflows.

Required Scientific Expertise

Degree: PhD in Pharmacology, Biology, Organic/Medicinal Chemistry, or related field.

Technical Knowledge: Deep understanding of the E3 ubiquitin ligase pathway, linker-payload chemistry, and the nuances of antibody-mediated intracellular delivery.

Preclinical Pharmacology: Oversee high-quality in vivo efficacy and toxicology studies. Ensure partners utilize validated, molecularly characterized models (CDX, PDX, humanized mice) essential for evaluating DACs in oncology and autoimmune indications.

Industry Experience: 7–10+ years in biotech/pharma with a track record of managing complex therapeutic modalities (ADCs, TPDs, or PROTACs).

Global-Local Mindset: Must possess the "combo" background—international scientific training (U.S./Europe) coupled with significant operational experience within the Chinese regulatory and CRO landscape.

Quality, Regulatory & IP Compliance

On-Site Audits: Coordinating on-site audits of laboratory facilities to ensure adherence to global GLP/GMP standards.

IP Protection: Work with the legal team to structure agreements that protect Orum’s proprietary platforms, ensuring clear data ownership and compliance with China’s specific IP regimes.

Skills

Bilingual Fluency: Oral and written proficiency in Mandarin and English is essential for navigating local networks and communicating with global leadership.

"Player-Coach" Mentality: Ability to operate independently in a self-managed environment while coordinating complex cross-border projects.

Negotiation: Strong ability to negotiate pricing and timelines with external vendors.

Cultural & Operational Perks

Impactful Leadership: Serve as a high-authority Orum representative to ensure effective oversight of large-scale external teams.

Modern Infrastructure Support: Full home-office setup stipend to facilitate seamless virtual collaboration with our global R&D leadership. 

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