Bioinformatics Intern

ElevateBio is a technology-driven cell and gene therapy company, accelerating access to the cutting-edge technologies and expertise to change the future of medicine. Our integrated technologies model offers turnkey scale and biotechnological capabilities to power genetic medicines processes, programs, and companies to their full potential.

The Role:

ElevateBio is looking for a motivated intern to support the Bioinformatics team housed in the Next-Generation Sequencing (NGS) Core at ElevateBio Basecamp.

Here’s What You’ll Do:

As part of developing a larger cross-functional workflow, the intern will focus on processing and analyzing single cell RNA sequencing experiments (scRNA-seq) from collaborative experiments with our Analytical Development and Process Development teams. From a bioinformatics lens, the intern will be included in experimental design discussions, wet lab preparation for sequencing, and manage the subsequent bioinformatics processing pipelines on the cloud (S3, EC2, AWS Batch, help edit reference for gene editing target coverage). The intern will also perform relevant downstream analysis (e.g., PCA, Pearson Correlation, differential expression, marker expression and cell typing with assistance as needed) and present outcomes. This project will help provide transcriptional information to be paired with other orthogonal and characterization assays such as flow cytometry and potency to provide a richer understanding of our manufactured cell therapy products.

Other routine tasks will include cloud-based data transfer, presenting to the NGS Core Team/larger groups, and supporting other bioinformatics projects as needed (e.g., run other processing pipelines).

• Collaborate on sequencing experimental design with the NGS Core wet lab and observe sample preparation

• Review sequence performance

• Run cloud-based processing pipelines

• Perform bioinformatics analyses of sequenced data using standard tools (BaseSpace, R/Python, AWS S3 and EC2, Seurat)

• Prepare visualizations to convey complex findings (Python/R)

• Assist in routine tasks such as data transfers, run other processing pipelines

• Present findings at team or department meetings including to Analytical Development and Process Development Teams

Requirements:

• Graduate or undergraduate student working towards a degree in bioinformatics, computational biology, data science, genomics or similar

• Experience using or working knowledge of common bioinformatic tools such as tools involved in quality control, alignment, and quantification or variant calling of NGS data

• Experience with at least one programming language (R or Python)

• Experience with, working knowledge of, or eagerness to work with cloud computing (AWS is a plus)

• Comfortable with fast pace, team-oriented environment

The budgeted range for this position is $25.00 per hour. This range is a good faith estimate of the expected hourly range for this position, based on a wide range of factors including qualifications, experience and training, operational and business needs and other considerations permitted by law.

Why Join ElevateBio?

ElevateBio is a technology-driven company built to power transformative genetic medicines today and for many decades to come. The Company commercializes its enabling technologies, manufacturing capabilities, and industry-leading expertise through partnerships to accelerate development across a breadth of therapeutic approaches and modalities. The ElevateBio ecosystem combines multiple R&D technology platforms – including Life Edit, a next-generation, full-spectrum gene editing platform; comprehensive cell engineering technologies; and an expanded viral and non-viral therapeutic delivery platform – with BaseCamp®, its end-to-end genetic medicine cGMP manufacturing and process development business, to accelerate the discovery and development of advanced therapeutics.

We aim to be the dominant engine inside the world’s greatest scientific advancements harnessing human cells and genes to alter disease.

Our Mission:
To power the creation of life-transforming cell and gene therapies, at a speed the world deserves.

Our Vision:
We seek to be the world’s most indispensable cell and gene therapy technology company, redefining how companies operate, how products are created and how disease is treated.

ElevateBio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. ElevateBio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.