Associate Scientist I, Discovery Chemistry (Bioconjugation)

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Arrowhead is seeking a highly motivated Associate Scientist to join our growing Discovery Chemistry team at our San Diego site. This individual will primarily focus on oligonucleotide bioconjugation, peptide synthesis, purification, and analytical chemistry. As a discovery chemist, you will play a key role in the development and optimization of siRNA-based therapeutics by applying your expertise in bioconjugation strategies and peptide chemistry.

Responsibilities

• Maintain a well-documented laboratory notebook

• Track progress against project timelines, generate regular status updates, and communicate progress and issues to management

• Perform tasks across projects

• Manage time effectively to meet deadlines

• Adhere to safe laboratory practices

• Prioritize and perform synthesis, purification, and analysis of conjugates based on project deliverable timelines

Requirements:

• B.S. or M.S. Chemistry or Biochemistry degree with excellent understanding of organic and analytical chemistry

• 0-3 years of experience working in a chemistry laboratory

• Experience with a wide range of analytical techniques, especially HPLC

• Ability to quickly learn new procedures and techniques

Preferred:

• Experience working with large-molecule synthetic targets, particularly oligonucleotides, in an academic or industry setting

• Experience with solid-phase peptide synthesis (automated and/or manual)

• Prior experience in a pharmaceutical or biotechnology environment

California pay range
$60,000—$80,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.

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